Cytokine expression and accelerated tooth movement

Cristina Teixeira, E. Khoo, J. Tran, I. Chartres, Y. Liu, L. M. Thant, I. Khabensky, L. P. Gart, George Cisneros, M. Alikhani

Research output: Contribution to journalArticle

Abstract

It has been shown that inhibiting the expression of certain cytokines decreases the rate of tooth movement. Here, we hypothesized that stimulating the expression of inflammatory cytokines, through small perforations of cortical bone, increases the rate of bone remodeling and tooth movement. Forty-eight rats were divided into 4 groups: 50-cN force applied to the maxillary first molar (O), force application plus soft tissue flap (OF), force application plus flap plus 3 small perforations of the cortical plate (OFP), and a control group (C). From the 92 cytokines studied, the expression of 37 cytokines increased significantly in all experimental groups, with 21 cytokines showing the highest levels in the OFP group. After 28 days, micro-computed tomography, light and fluorescent microscopy, and immunohistochemistry demonstrated higher numbers of osteoclasts and bone remodeling activity in the OFP group, accompanied by generalized osteoporosity and increased rate of tooth movement.

Original languageEnglish (US)
Pages (from-to)1135-1141
Number of pages7
JournalJournal of Dental Research
Volume89
Issue number10
DOIs
StatePublished - Oct 2010

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Tooth Movement Techniques
Cytokines
Bone Remodeling
Osteoclasts
Cerebral Cortex
Microscopy
Immunohistochemistry
Tomography
Light
Control Groups

Keywords

  • bone remodeling
  • cytokines
  • osteoperforation
  • tooth movement

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Teixeira, C., Khoo, E., Tran, J., Chartres, I., Liu, Y., Thant, L. M., ... Alikhani, M. (2010). Cytokine expression and accelerated tooth movement. Journal of Dental Research, 89(10), 1135-1141. https://doi.org/10.1177/0022034510373764

Cytokine expression and accelerated tooth movement. / Teixeira, Cristina; Khoo, E.; Tran, J.; Chartres, I.; Liu, Y.; Thant, L. M.; Khabensky, I.; Gart, L. P.; Cisneros, George; Alikhani, M.

In: Journal of Dental Research, Vol. 89, No. 10, 10.2010, p. 1135-1141.

Research output: Contribution to journalArticle

Teixeira, C, Khoo, E, Tran, J, Chartres, I, Liu, Y, Thant, LM, Khabensky, I, Gart, LP, Cisneros, G & Alikhani, M 2010, 'Cytokine expression and accelerated tooth movement', Journal of Dental Research, vol. 89, no. 10, pp. 1135-1141. https://doi.org/10.1177/0022034510373764
Teixeira C, Khoo E, Tran J, Chartres I, Liu Y, Thant LM et al. Cytokine expression and accelerated tooth movement. Journal of Dental Research. 2010 Oct;89(10):1135-1141. https://doi.org/10.1177/0022034510373764
Teixeira, Cristina ; Khoo, E. ; Tran, J. ; Chartres, I. ; Liu, Y. ; Thant, L. M. ; Khabensky, I. ; Gart, L. P. ; Cisneros, George ; Alikhani, M. / Cytokine expression and accelerated tooth movement. In: Journal of Dental Research. 2010 ; Vol. 89, No. 10. pp. 1135-1141.
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