Abstract
We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.
| Original language | English (US) |
|---|---|
| Article number | 9181 |
| Journal | Scientific Reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2017 |
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Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling. / Ono, Kentaro; Viet, Chi T.; Ye, Yi; Dang, Dongmin; Hitomi, Suzuro; Toyono, Takashi; Inenaga, Kiyotoshi; Dolan, John C.; Schmidt, Brian.
In: Scientific Reports, Vol. 7, No. 1, 9181, 01.12.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
AU - Ono, Kentaro
AU - Viet, Chi T.
AU - Ye, Yi
AU - Dang, Dongmin
AU - Hitomi, Suzuro
AU - Toyono, Takashi
AU - Inenaga, Kiyotoshi
AU - Dolan, John C.
AU - Schmidt, Brian
PY - 2017/12/1
Y1 - 2017/12/1
N2 - We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.
AB - We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.
UR - http://www.scopus.com/inward/record.url?scp=85027960735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027960735&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-09682-4
DO - 10.1038/s41598-017-09682-4
M3 - Article
C2 - 28835637
AN - SCOPUS:85027960735
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 9181
ER -