Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design

Jeffrey D. Rimer, Zhihua An, Zina Zhu, Michael H. Lee, David S. Goldfarb, Jeffrey A. Wesson, Michael Ward

Research output: Contribution to journalArticle

Abstract

Crystallization of L-cystine is a critical step in the pathogenesis of cystine kidney stones. Treatments for this disease are somewhat effective but often lead to adverse side effects. Real-time in situ atomic force microscopy (AFM) reveals that L-cystine dimethylester (L-CDME) and L-cystine methylester (L-CME) dramatically reduce the growth velocity of the six symmetry-equivalent {100} steps because of specific binding at the crystal surface, which frustrates the attachment of L-cystine molecules. L-CDME and L-CME produce L-cystine crystals with different habits that reveal distinct binding modes at the crystal surfaces. The AFM observations are mirrored by reduced crystal yield and crystal size in the presence of L-CDME and L-CME, collectively suggesting a new pathway to the prevention of L-cystine stones by rational design of crystal growth inhibitors.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalScience
Volume330
Issue number6002
DOIs
StatePublished - Oct 15 2010

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Growth Inhibitors
Kidney Calculi
Cystine
Crystallization
Atomic Force Microscopy
Habits
Growth
L-cystine methylester
L-cystine dimethylester

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Rimer, J. D., An, Z., Zhu, Z., Lee, M. H., Goldfarb, D. S., Wesson, J. A., & Ward, M. (2010). Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design. Science, 330(6002), 337-341. https://doi.org/10.1126/science.1191968

Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design. / Rimer, Jeffrey D.; An, Zhihua; Zhu, Zina; Lee, Michael H.; Goldfarb, David S.; Wesson, Jeffrey A.; Ward, Michael.

In: Science, Vol. 330, No. 6002, 15.10.2010, p. 337-341.

Research output: Contribution to journalArticle

Rimer, JD, An, Z, Zhu, Z, Lee, MH, Goldfarb, DS, Wesson, JA & Ward, M 2010, 'Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design', Science, vol. 330, no. 6002, pp. 337-341. https://doi.org/10.1126/science.1191968
Rimer JD, An Z, Zhu Z, Lee MH, Goldfarb DS, Wesson JA et al. Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design. Science. 2010 Oct 15;330(6002):337-341. https://doi.org/10.1126/science.1191968
Rimer, Jeffrey D. ; An, Zhihua ; Zhu, Zina ; Lee, Michael H. ; Goldfarb, David S. ; Wesson, Jeffrey A. ; Ward, Michael. / Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design. In: Science. 2010 ; Vol. 330, No. 6002. pp. 337-341.
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