Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish

Nicolas Rohner, Dan F. Jarosz, Johanna E. Kowalko, Masato Yoshizawa, William R. Jeffery, Richard L. Borowsky, Susan Lindquist, Clifford J. Tabin

Research output: Contribution to journalArticle

Abstract

In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting.

Original languageEnglish (US)
Pages (from-to)1372-1375
Number of pages4
JournalScience
Volume342
Issue number6164
DOIs
StatePublished - 2013

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Protein
Heat
Fish
Natural Selection
Unmasking
Substrate
Tax
Mask
Phenotype

ASJC Scopus subject areas

  • General
  • History and Philosophy of Science

Cite this

Rohner, N., Jarosz, D. F., Kowalko, J. E., Yoshizawa, M., Jeffery, W. R., Borowsky, R. L., ... Tabin, C. J. (2013). Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science, 342(6164), 1372-1375. https://doi.org/10.1126/science.1240276

Cryptic variation in morphological evolution : HSP90 as a capacitor for loss of eyes in cavefish. / Rohner, Nicolas; Jarosz, Dan F.; Kowalko, Johanna E.; Yoshizawa, Masato; Jeffery, William R.; Borowsky, Richard L.; Lindquist, Susan; Tabin, Clifford J.

In: Science, Vol. 342, No. 6164, 2013, p. 1372-1375.

Research output: Contribution to journalArticle

Rohner, N, Jarosz, DF, Kowalko, JE, Yoshizawa, M, Jeffery, WR, Borowsky, RL, Lindquist, S & Tabin, CJ 2013, 'Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish', Science, vol. 342, no. 6164, pp. 1372-1375. https://doi.org/10.1126/science.1240276
Rohner, Nicolas ; Jarosz, Dan F. ; Kowalko, Johanna E. ; Yoshizawa, Masato ; Jeffery, William R. ; Borowsky, Richard L. ; Lindquist, Susan ; Tabin, Clifford J. / Cryptic variation in morphological evolution : HSP90 as a capacitor for loss of eyes in cavefish. In: Science. 2013 ; Vol. 342, No. 6164. pp. 1372-1375.
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