Cross-regulatory interactions among pair-rule genes in Drosophila

K. Harding, C. Rushlow, H. J. Doyle, T. Hoey, M. Levine

Research output: Contribution to journalArticle

Abstract

The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve - embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve - phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.

Original languageEnglish (US)
Pages (from-to)953-959
Number of pages7
JournalScience
Volume233
Issue number4767
DOIs
StatePublished - 1986

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Drosophila
Embryonic Structures
Genes
Body Regions
Homeobox Genes
Phenotype
Gene Expression

ASJC Scopus subject areas

  • General

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Cross-regulatory interactions among pair-rule genes in Drosophila. / Harding, K.; Rushlow, C.; Doyle, H. J.; Hoey, T.; Levine, M.

In: Science, Vol. 233, No. 4767, 1986, p. 953-959.

Research output: Contribution to journalArticle

Harding, K, Rushlow, C, Doyle, HJ, Hoey, T & Levine, M 1986, 'Cross-regulatory interactions among pair-rule genes in Drosophila', Science, vol. 233, no. 4767, pp. 953-959. https://doi.org/10.1126/science.3755551
Harding, K. ; Rushlow, C. ; Doyle, H. J. ; Hoey, T. ; Levine, M. / Cross-regulatory interactions among pair-rule genes in Drosophila. In: Science. 1986 ; Vol. 233, No. 4767. pp. 953-959.
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