Critical examination of Fe8 as a contrast agent for magnetic resonance imaging

Steven Isaacman, Rajeev Kumar, Enrique Del Barco, Andrew D. Kent, James Canary, Alexej Jerschow

Research output: Contribution to journalArticle

Abstract

The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.

Original languageEnglish (US)
Pages (from-to)2691-2694
Number of pages4
JournalPolyhedron
Volume24
Issue number16-17
DOIs
StatePublished - Nov 17 2005

Fingerprint

Magnetic resonance
Contrast Media
magnetic resonance
Pentetic Acid
Gadolinium DTPA
examination
Magnetic Resonance Imaging
aqueous solutions
Imaging techniques
Superparamagnetism
Molecular imaging
Molecular Imaging
recovery
inversions
nuclear magnetic resonance
acids
Nuclear magnetic resonance
Recovery
Acids

Keywords

  • Contrast agent
  • Magnetic resonance imaging
  • Relaxation
  • Single-molecule magnet
  • Superparamagnet

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Critical examination of Fe8 as a contrast agent for magnetic resonance imaging. / Isaacman, Steven; Kumar, Rajeev; Barco, Enrique Del; Kent, Andrew D.; Canary, James; Jerschow, Alexej.

In: Polyhedron, Vol. 24, No. 16-17, 17.11.2005, p. 2691-2694.

Research output: Contribution to journalArticle

Isaacman, Steven ; Kumar, Rajeev ; Barco, Enrique Del ; Kent, Andrew D. ; Canary, James ; Jerschow, Alexej. / Critical examination of Fe8 as a contrast agent for magnetic resonance imaging. In: Polyhedron. 2005 ; Vol. 24, No. 16-17. pp. 2691-2694.
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