Abstract
The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2691-2694 |
| Number of pages | 4 |
| Journal | Polyhedron |
| Volume | 24 |
| Issue number | 16-17 |
| DOIs | |
| State | Published - Nov 17 2005 |
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Keywords
- Contrast agent
- Magnetic resonance imaging
- Relaxation
- Single-molecule magnet
- Superparamagnet
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Physical and Theoretical Chemistry
- Materials Chemistry
Cite this
Critical examination of Fe8 as a contrast agent for magnetic resonance imaging. / Isaacman, Steven; Kumar, Rajeev; Barco, Enrique Del; Kent, Andrew D.; Canary, James; Jerschow, Alexej.
In: Polyhedron, Vol. 24, No. 16-17, 17.11.2005, p. 2691-2694.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Critical examination of Fe8 as a contrast agent for magnetic resonance imaging
AU - Isaacman, Steven
AU - Kumar, Rajeev
AU - Barco, Enrique Del
AU - Kent, Andrew D.
AU - Canary, James
AU - Jerschow, Alexej
PY - 2005/11/17
Y1 - 2005/11/17
N2 - The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.
AB - The compound Fe8 (C36H120O 23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous solutions of Fe8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T1 and T2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe 8 solutions was found to be weak compared to Gd(DTPA). However, an interesting dependence upon pH was observed. The influence of environmental factors on relaxivity is of interest in the burgeoning field of molecular imaging.
KW - Contrast agent
KW - Magnetic resonance imaging
KW - Relaxation
KW - Single-molecule magnet
KW - Superparamagnet
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UR - http://www.scopus.com/inward/citedby.url?scp=27644489103&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2005.03.138
DO - 10.1016/j.poly.2005.03.138
M3 - Article
AN - SCOPUS:27644489103
VL - 24
SP - 2691
EP - 2694
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
IS - 16-17
ER -