Creating sub-50 nm nanofluidic junctions in a PDMS microchip via self-assembly process of colloidal silica beads for electrokinetic concentration of biomolecules

A. Syed, L. Mangano, P. Mao, J. Han, Y. A. Song

Research output: Contribution to journalArticle


In this work we describe a novel and simple self-assembly process of colloidal silica beads to create a nanofluidic junction between two microchannels. The nanoporous membrane was used to induce ion concentration polarization inside the microchannel and this electrokinetic preconcentration system allowed rapid concentration of DNA samples by ~1700 times and of protein samples by ~100 times within 5 minutes. This journal is

Original languageEnglish (US)
Pages (from-to)4455-4460
Number of pages6
JournalLab on a Chip
Issue number23
StatePublished - Dec 7 2014


ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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