Crafting precise multivalent architectures

Paul M. Levine, Tom P. Carberry, Justin M. Holub, Kent Kirshenbaum

Research output: Contribution to journalArticle

Abstract

Multivalency is a powerful strategy in molecular pharmacology that can establish high-affinity binding between multiple conjoined ligands and corresponding biomolecular targets. Recent advances in chemical synthesis techniques have enabled the development of elaborate two-dimensional multivalent displays appended on natural or synthetic molecular scaffolds. These constructs have the potential to address disease targets that otherwise may be classified as 'undruggable.' In this review, synthetic strategies to generate and functionalize different classes of scaffolds are evaluated. Particular focus is placed on crafting multivalent assemblies that occupy a 'middle space' of molecular weight, along with a consideration of their potential applications in pharmacology.

Original languageEnglish (US)
Pages (from-to)493-509
Number of pages17
JournalMedChemComm
Volume4
Issue number3
DOIs
StatePublished - Mar 2013

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Scaffolds
Pharmacology
Molecular Weight
Molecular weight
Display devices
Ligands

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Levine, P. M., Carberry, T. P., Holub, J. M., & Kirshenbaum, K. (2013). Crafting precise multivalent architectures. MedChemComm, 4(3), 493-509. https://doi.org/10.1039/c2md20338c

Crafting precise multivalent architectures. / Levine, Paul M.; Carberry, Tom P.; Holub, Justin M.; Kirshenbaum, Kent.

In: MedChemComm, Vol. 4, No. 3, 03.2013, p. 493-509.

Research output: Contribution to journalArticle

Levine, PM, Carberry, TP, Holub, JM & Kirshenbaum, K 2013, 'Crafting precise multivalent architectures', MedChemComm, vol. 4, no. 3, pp. 493-509. https://doi.org/10.1039/c2md20338c
Levine, Paul M. ; Carberry, Tom P. ; Holub, Justin M. ; Kirshenbaum, Kent. / Crafting precise multivalent architectures. In: MedChemComm. 2013 ; Vol. 4, No. 3. pp. 493-509.
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