CRAC channels in dental enamel cells

M. Eckstein, Rodrigo Lacruz

Research output: Contribution to journalReview article

Abstract

Enamel mineralization relies on Ca2+ availability provided by Ca2+ release activated Ca2+ (CRAC) channels. CRAC channels are modulated by the endoplasmic reticulum Ca2+ sensor STIM1 which gates the pore subunit of the channel known as ORAI1, found the in plasma membrane, to enable sustained Ca2+ influx. Mutations in the STIM1 and ORAI1 genes result in CRAC channelopathy, an ensemble of diseases including immunodeficiency, muscular hypotonia, ectodermal dysplasia with defects in sweat gland function and abnormal enamel mineralization similar to amelogenesis imperfecta (AI). In some reports, the chief medical complain has been the patient's dental health, highlighting the direct and important link between CRAC channels and enamel. The reported enamel defects are apparent in both the deciduous and in permanent teeth and often require extensive dental treatment to provide the patient with a functional dentition. Among the dental phenotypes observed in the patients, discoloration, increased wear, hypoplasias (thinning of enamel) and chipping has been reported. These findings are not universal in all patients. Here we review the mutations in STIM1 and ORAI1 causing AI-like phenotype, and evaluate the enamel defects in CRAC channel deficient mice. We also provide a brief overview of the role of CRAC channels in other mineralizing systems such as dentine and bone.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalCell Calcium
Volume75
DOIs
StatePublished - Nov 1 2018

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Dental Enamel
Tooth
Amelogenesis Imperfecta
Dental Enamel Hypoplasia
Channelopathies
Ectodermal Dysplasia
Phenotype
Sweat Glands
Mutation
Muscle Hypotonia
Dentition
Dentin
Endoplasmic Reticulum
Cell Membrane
Bone and Bones
Health
Genes
Therapeutics

Keywords

  • Amelogenesis imperfecta
  • CRAC channels
  • Enamel
  • Hypoplasia
  • Mutations

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

CRAC channels in dental enamel cells. / Eckstein, M.; Lacruz, Rodrigo.

In: Cell Calcium, Vol. 75, 01.11.2018, p. 14-20.

Research output: Contribution to journalReview article

Eckstein, M. ; Lacruz, Rodrigo. / CRAC channels in dental enamel cells. In: Cell Calcium. 2018 ; Vol. 75. pp. 14-20.
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