Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, Risheng Wang, James W. Canary, Nadrian C. Seeman

Research output: Contribution to journalArticle


We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Original languageEnglish (US)
Pages (from-to)10882-10883
Number of pages2
JournalJournal of the American Chemical Society
Issue number33
StatePublished - Aug 20 2008


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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