Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, Risheng Wang, James Canary, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5′- and 3′-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Original languageEnglish (US)
Pages (from-to)10882-10883
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number33
DOIs
StatePublished - Aug 20 2008

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Catenated DNA
DNA
Amides
catenane

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Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini. / Liu, Yu; Kuzuya, Akinori; Sha, Ruojie; Guillaume, Johan; Wang, Risheng; Canary, James; Seeman, Nadrian.

In: Journal of the American Chemical Society, Vol. 130, No. 33, 20.08.2008, p. 10882-10883.

Research output: Contribution to journalArticle

Liu, Yu ; Kuzuya, Akinori ; Sha, Ruojie ; Guillaume, Johan ; Wang, Risheng ; Canary, James ; Seeman, Nadrian. / Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 33. pp. 10882-10883.
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