Cortical Maps and White Matter Tracts following Long Period of Visual Deprivation and Retinal Image Restoration

Netta Levin, Serge O. Dumoulin, Jonathan Winawer, Robert F. Dougherty, Brian A. Wandell

Research output: Contribution to journalArticle

Abstract

Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven years following the surgery, remain severely limited, and he does not rely on vision for daily life. Neuroimaging measurements reveal several differences among MM, sighted controls, sighted monocular, and early blind subjects. We speculate that these differences stem from damage during the critical period in development of retinal neurons with small, foveal receptive fields. In this case, restoration of functional vision requires more than improving retinal image contrast. In general, visual restoration will require accounting for the developmental trajectory of the individual and the consequences of the early deprivation on cortical circuitry.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalNeuron
Volume65
Issue number1
DOIs
StatePublished - Jan 14 2010

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Retinal Neurons
Aptitude
Neuroimaging
White Matter
Critical Period (Psychology)
Corneal Injuries

Keywords

  • HUMDISEASE
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cortical Maps and White Matter Tracts following Long Period of Visual Deprivation and Retinal Image Restoration. / Levin, Netta; Dumoulin, Serge O.; Winawer, Jonathan; Dougherty, Robert F.; Wandell, Brian A.

In: Neuron, Vol. 65, No. 1, 14.01.2010, p. 21-31.

Research output: Contribution to journalArticle

Levin, Netta ; Dumoulin, Serge O. ; Winawer, Jonathan ; Dougherty, Robert F. ; Wandell, Brian A. / Cortical Maps and White Matter Tracts following Long Period of Visual Deprivation and Retinal Image Restoration. In: Neuron. 2010 ; Vol. 65, No. 1. pp. 21-31.
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