Cortical gray and white brain tissue volume in adolescents and adults with autism

Heather Cody Hazlett, Michele D. Poe, Guido Gerig, Rachel Gimpel Smith, Joseph Piven

    Research output: Contribution to journalArticle

    Abstract

    Background: A number of studies have found brain enlargement in autism, but there is disagreement as to whether this enlargement is limited to early development or continues into adulthood. In this study, cortical gray and white tissue volumes were examined in a sample of adolescents and adults with autism who had demonstrated total brain enlargement in a previous magnetic resonance imaging (MRI) study. Methods: An automated tissue segmentation program was applied to structural MRI scans to obtain volumes of gray, white, and cerebrospinal fluid (CSF) tissue on a sample of adolescent and adult males ages 13-29 with autism (n = 23) and controls (n = 15). Regional differences for brain lobes and brain hemispheres were also examined. Results: Significant enlargement in gray matter volume was found for the individuals with autism, with a disproportionate increase in left-sided gray matter volume. Lobe volume enlargements were detected for frontal and temporal, but not parietal or occipital lobes, in the subjects with autism. Age and nonverbal IQ effects on tissue volume were also observed. Conclusions: These findings give evidence for left-lateralized gray tissue enlargement in adolescents and adults with autism, and demonstrate a regional pattern of cortical lobe volumes underlying this effect.

    Original languageEnglish (US)
    Pages (from-to)1-6
    Number of pages6
    JournalBiological Psychiatry
    Volume59
    Issue number1
    DOIs
    StatePublished - Jan 1 2006

    Fingerprint

    Autistic Disorder
    Brain
    Magnetic Resonance Imaging
    Occipital Lobe
    Parietal Lobe
    Cerebrospinal Fluid

    Keywords

    • Adolescent/adult
    • Autism
    • Brain
    • MRI
    • Neuroimaging
    • Tissue volume

    ASJC Scopus subject areas

    • Biological Psychiatry

    Cite this

    Cortical gray and white brain tissue volume in adolescents and adults with autism. / Hazlett, Heather Cody; Poe, Michele D.; Gerig, Guido; Smith, Rachel Gimpel; Piven, Joseph.

    In: Biological Psychiatry, Vol. 59, No. 1, 01.01.2006, p. 1-6.

    Research output: Contribution to journalArticle

    Hazlett, Heather Cody ; Poe, Michele D. ; Gerig, Guido ; Smith, Rachel Gimpel ; Piven, Joseph. / Cortical gray and white brain tissue volume in adolescents and adults with autism. In: Biological Psychiatry. 2006 ; Vol. 59, No. 1. pp. 1-6.
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