Cortical correlates of amblyopia

Lynne Kiorpes, Nigel Daw

Research output: Contribution to journalReview article

Abstract

There are many levels of disorder in amblyopic vision, from basic acuity and contrast sensitivity loss to abnormal binocular vision and global perception of motion and form. Amblyopia treatment via patching to restore acuity often leaves other aspects of vision deficient. The source for these additional deficits is unclear. Neural correlates of poor binocular function and acuity loss are found in V1 and V2. However, they are generally not sufficient to account for behaviorally measured vision loss. This review summarizes the known cortical correlates of visual deficits found in association with amblyopia, particularly those relevant to binocular vision and higher-order visual processing, in striate and extrastriate cortex. Recommendations for future research address open questions on the role of suppression and oculomotor abnormalities in amblyopic vision, and underexplored mechanisms such as top-down influences on information transmission in the amblyopic brain.

Original languageEnglish (US)
Pages (from-to)E016
JournalVisual Neuroscience
Volume35
DOIs
StatePublished - Jan 1 2018

Fingerprint

Amblyopia
Binocular Vision
Visual Cortex
Form Perception
Motion Perception
Contrast Sensitivity
Brain
Therapeutics

Keywords

  • Extrastriate cortex
  • Interocular suppression
  • Sensitive periods
  • Striate cortex
  • Visual-motor integration

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

Cite this

Cortical correlates of amblyopia. / Kiorpes, Lynne; Daw, Nigel.

In: Visual Neuroscience, Vol. 35, 01.01.2018, p. E016.

Research output: Contribution to journalReview article

Kiorpes, Lynne ; Daw, Nigel. / Cortical correlates of amblyopia. In: Visual Neuroscience. 2018 ; Vol. 35. pp. E016.
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