Cortical and trabecular bone healing patterns and quantification for three different dental implant systems

Heloisa F. Marão, Ryo Jimbo, Rodrigo Neiva, Luiz Fernando Gil, Michelle Bowers, Estevam A. Bonfante, Nick Tovar, Malvin N. Janal, Paulo Coelho

Research output: Contribution to journalArticle

Abstract

Purpose: The present study hypothesized that different bone healing patterns through initial stages of osseointegration would be observed when three distinct commercially available implant systems (Nobel Groovy, Implacil, and Zimmer TSV) were used, leading to significant variations in histometric levels of total bone and new bone formation during the osseointegration process. Materials and Methods: A total of 48 implants were placed bilaterally on the tibias of eight beagle dogs and allowed to heal for 2 and 6 weeks. Following euthanasia, nondecalcified specimens were processed for morphologic and histometric evaluation. Bone-to-implant contact (BIC) and new bone area fraction occupancy (BAFO) analyses for native and new bone were performed along the whole perimeter of each implant and separately for the cortical and trabecular bone regions. Results: Morphologic evaluation of cortical bone presented different healing patterns and osseointegration levels for different implant systems as time elapsed in vivo. Interfacial remodeling was the chief healing pattern in Zimmer implants, while a combination of interfacial remodeling and healing chambers was observed in Nobel and Implacil implants. When trabecular bone was evaluated, similar bone healing patterns were observed between systems despite different levels of osseointegration observed as a function of implantation time, implant system, and native and/or new bone BIC and BAFO. Conclusion: Different implant systems led to different healing patterns during early stages of osseointegration. Such variation in pattern was more noticeable in the cortical regions compared to the trabecular regions. The variation in bone healing pattern did significantly influence overall indicators of native and new BIC and BAFO during the osseointegration process. The postulated hypothesis was accepted.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Implants
Volume32
Issue number3
DOIs
StatePublished - 2017

Fingerprint

Dental Implants
Osseointegration
Bone and Bones
Cancellous Bone
Cortical Bone
Euthanasia
Tibia
Osteogenesis
Dogs

Keywords

  • Bone marrow
  • Dental implants
  • Design
  • Histology
  • Osseointegration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cortical and trabecular bone healing patterns and quantification for three different dental implant systems. / Marão, Heloisa F.; Jimbo, Ryo; Neiva, Rodrigo; Gil, Luiz Fernando; Bowers, Michelle; Bonfante, Estevam A.; Tovar, Nick; Janal, Malvin N.; Coelho, Paulo.

In: International Journal of Oral and Maxillofacial Implants, Vol. 32, No. 3, 2017, p. 585-592.

Research output: Contribution to journalArticle

Marão, Heloisa F. ; Jimbo, Ryo ; Neiva, Rodrigo ; Gil, Luiz Fernando ; Bowers, Michelle ; Bonfante, Estevam A. ; Tovar, Nick ; Janal, Malvin N. ; Coelho, Paulo. / Cortical and trabecular bone healing patterns and quantification for three different dental implant systems. In: International Journal of Oral and Maxillofacial Implants. 2017 ; Vol. 32, No. 3. pp. 585-592.
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abstract = "Purpose: The present study hypothesized that different bone healing patterns through initial stages of osseointegration would be observed when three distinct commercially available implant systems (Nobel Groovy, Implacil, and Zimmer TSV) were used, leading to significant variations in histometric levels of total bone and new bone formation during the osseointegration process. Materials and Methods: A total of 48 implants were placed bilaterally on the tibias of eight beagle dogs and allowed to heal for 2 and 6 weeks. Following euthanasia, nondecalcified specimens were processed for morphologic and histometric evaluation. Bone-to-implant contact (BIC) and new bone area fraction occupancy (BAFO) analyses for native and new bone were performed along the whole perimeter of each implant and separately for the cortical and trabecular bone regions. Results: Morphologic evaluation of cortical bone presented different healing patterns and osseointegration levels for different implant systems as time elapsed in vivo. Interfacial remodeling was the chief healing pattern in Zimmer implants, while a combination of interfacial remodeling and healing chambers was observed in Nobel and Implacil implants. When trabecular bone was evaluated, similar bone healing patterns were observed between systems despite different levels of osseointegration observed as a function of implantation time, implant system, and native and/or new bone BIC and BAFO. Conclusion: Different implant systems led to different healing patterns during early stages of osseointegration. Such variation in pattern was more noticeable in the cortical regions compared to the trabecular regions. The variation in bone healing pattern did significantly influence overall indicators of native and new BIC and BAFO during the osseointegration process. The postulated hypothesis was accepted.",
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AU - Bonfante, Estevam A.

AU - Tovar, Nick

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