Controlling curvature in a family of oligoamide α-helix mimetics

Ishu Saraogi, Christopher D. Incarvito, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices.

Original languageEnglish (US)
Pages (from-to)9691-9694
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number50
DOIs
StatePublished - Dec 1 2008

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Scaffolds
Hydrogen bonds

Keywords

  • Curvature
  • Helical structures
  • Hydrogen bonds
  • Oligoamides
  • Proteomimetics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Controlling curvature in a family of oligoamide α-helix mimetics. / Saraogi, Ishu; Incarvito, Christopher D.; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 47, No. 50, 01.12.2008, p. 9691-9694.

Research output: Contribution to journalArticle

Saraogi, Ishu ; Incarvito, Christopher D. ; Hamilton, Andrew. / Controlling curvature in a family of oligoamide α-helix mimetics. In: Angewandte Chemie - International Edition. 2008 ; Vol. 47, No. 50. pp. 9691-9694.
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