Abstract
Neurons in the medial superior olive process sound-localization cues via binaural coincidence detection, in which excitatory synaptic inputs from each ear are segregated onto different branches of a bipolar dendritic structure and summed at the soma and axon with submillisecond time resolution. Although synaptic timing and dynamics critically shape this computation, synaptic interactions with intrinsic ion channels have received less attention. Using paired somatic and dendritic patch-clamp recordings in gerbil brainstem slices together with compartmental modeling, we found that activation of K v 1 channels by dendritic excitatory postsynaptic potentials (EPSPs) accelerated membrane repolarization in a voltage-dependent manner and actively improved the time resolution of synaptic integration. We found that a somatically biased gradient of K v 1 channels underlies the degree of compensation for passive cable filtering during propagation of EPSPs in dendrites. Thus, both the spatial distribution and properties of K v 1 channels are important for preserving binaural synaptic timing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 601-609 |
| Number of pages | 9 |
| Journal | Nature Neuroscience |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2010 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Control of submillisecond synaptic timing in binaural coincidence detectors by K v 1 channels. / Mathews, Paul J.; Jercog, Pablo E.; Rinzel, John; Scott, Luisa L.; Golding, Nace L.
In: Nature Neuroscience, Vol. 13, No. 5, 05.2010, p. 601-609.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Control of submillisecond synaptic timing in binaural coincidence detectors by K v 1 channels
AU - Mathews, Paul J.
AU - Jercog, Pablo E.
AU - Rinzel, John
AU - Scott, Luisa L.
AU - Golding, Nace L.
PY - 2010/5
Y1 - 2010/5
N2 - Neurons in the medial superior olive process sound-localization cues via binaural coincidence detection, in which excitatory synaptic inputs from each ear are segregated onto different branches of a bipolar dendritic structure and summed at the soma and axon with submillisecond time resolution. Although synaptic timing and dynamics critically shape this computation, synaptic interactions with intrinsic ion channels have received less attention. Using paired somatic and dendritic patch-clamp recordings in gerbil brainstem slices together with compartmental modeling, we found that activation of K v 1 channels by dendritic excitatory postsynaptic potentials (EPSPs) accelerated membrane repolarization in a voltage-dependent manner and actively improved the time resolution of synaptic integration. We found that a somatically biased gradient of K v 1 channels underlies the degree of compensation for passive cable filtering during propagation of EPSPs in dendrites. Thus, both the spatial distribution and properties of K v 1 channels are important for preserving binaural synaptic timing.
AB - Neurons in the medial superior olive process sound-localization cues via binaural coincidence detection, in which excitatory synaptic inputs from each ear are segregated onto different branches of a bipolar dendritic structure and summed at the soma and axon with submillisecond time resolution. Although synaptic timing and dynamics critically shape this computation, synaptic interactions with intrinsic ion channels have received less attention. Using paired somatic and dendritic patch-clamp recordings in gerbil brainstem slices together with compartmental modeling, we found that activation of K v 1 channels by dendritic excitatory postsynaptic potentials (EPSPs) accelerated membrane repolarization in a voltage-dependent manner and actively improved the time resolution of synaptic integration. We found that a somatically biased gradient of K v 1 channels underlies the degree of compensation for passive cable filtering during propagation of EPSPs in dendrites. Thus, both the spatial distribution and properties of K v 1 channels are important for preserving binaural synaptic timing.
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U2 - 10.1038/nn.2530
DO - 10.1038/nn.2530
M3 - Article
C2 - 20364143
AN - SCOPUS:77951665282
VL - 13
SP - 601
EP - 609
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 5
ER -