Control of submillisecond synaptic timing in binaural coincidence detectors by K v 1 channels

Paul J. Mathews, Pablo E. Jercog, John Rinzel, Luisa L. Scott, Nace L. Golding

Research output: Contribution to journalArticle

Abstract

Neurons in the medial superior olive process sound-localization cues via binaural coincidence detection, in which excitatory synaptic inputs from each ear are segregated onto different branches of a bipolar dendritic structure and summed at the soma and axon with submillisecond time resolution. Although synaptic timing and dynamics critically shape this computation, synaptic interactions with intrinsic ion channels have received less attention. Using paired somatic and dendritic patch-clamp recordings in gerbil brainstem slices together with compartmental modeling, we found that activation of K v 1 channels by dendritic excitatory postsynaptic potentials (EPSPs) accelerated membrane repolarization in a voltage-dependent manner and actively improved the time resolution of synaptic integration. We found that a somatically biased gradient of K v 1 channels underlies the degree of compensation for passive cable filtering during propagation of EPSPs in dendrites. Thus, both the spatial distribution and properties of K v 1 channels are important for preserving binaural synaptic timing.

Original languageEnglish (US)
Pages (from-to)601-609
Number of pages9
JournalNature Neuroscience
Volume13
Issue number5
DOIs
StatePublished - May 2010

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Excitatory Postsynaptic Potentials
Sound Localization
Gerbillinae
Carisoprodol
Dendrites
Ion Channels
Brain Stem
Cues
Ear
Axons
Neurons
Membranes
Superior Olivary Complex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Control of submillisecond synaptic timing in binaural coincidence detectors by K v 1 channels. / Mathews, Paul J.; Jercog, Pablo E.; Rinzel, John; Scott, Luisa L.; Golding, Nace L.

In: Nature Neuroscience, Vol. 13, No. 5, 05.2010, p. 601-609.

Research output: Contribution to journalArticle

Mathews, Paul J. ; Jercog, Pablo E. ; Rinzel, John ; Scott, Luisa L. ; Golding, Nace L. / Control of submillisecond synaptic timing in binaural coincidence detectors by K v 1 channels. In: Nature Neuroscience. 2010 ; Vol. 13, No. 5. pp. 601-609.
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