Control of stem cell fate and function by polymer nanofibers

Deepti Rana, Maria Leena, Manasseh Nithyananth, Renu Pasricha, Geetha Manivasagam, Murugan Ramalingam

Research output: Contribution to journalArticle

Abstract

Stem cells are considered as an integral part of tissue engineering and regenerative medicine. Cellular functions of stem cells, which are responsible for tissue organization, can be controlled and regulated by providing an appropriate microenvironment, which mimics native stem cell niche. Nanotechnology is a powerful tool for engineering cellular microenvironment in the form of scaffolds. The scaffolds that have nanoscale features, for example, nanofiber, are considered as an effective substratum for tissue regenerative applications because they structurally mimic the native extracellular matrix (ECM). Electrospinning is a technique which produces polymer nanofiber scaffolds with controlled size and orientation of the fibrous structure. These polymer nanofibers can be used to control stem cell fate and function, in particular cell adhesion, proliferation and differentiation, during tissue engineering. In this article, we focus on recent developments and research trends in polymer nanofibrous scaffolds and their impact in controlling and regulating stem cell fate and function.

Original languageEnglish (US)
Pages (from-to)9015-9021
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Nanofibers
stem cells
Stem cells
Polymers
Stem Cells
Scaffolds
polymers
Tissue Engineering
tissue engineering
Tissue engineering
Stem Cell Niche
Cellular Microenvironment
Nanotechnology
Regenerative Medicine
Tissue
Forms (concrete)
Cell Adhesion
Cell adhesion
Extracellular Matrix
Electrospinning

Keywords

  • Cell-Material Interaction
  • Nanofibers
  • Scaffolds
  • Stem Cells
  • Tissue Engineering

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Rana, D., Leena, M., Nithyananth, M., Pasricha, R., Manivasagam, G., & Ramalingam, M. (2016). Control of stem cell fate and function by polymer nanofibers. Journal of Nanoscience and Nanotechnology, 16(9), 9015-9021. https://doi.org/10.1166/jnn.2016.12735

Control of stem cell fate and function by polymer nanofibers. / Rana, Deepti; Leena, Maria; Nithyananth, Manasseh; Pasricha, Renu; Manivasagam, Geetha; Ramalingam, Murugan.

In: Journal of Nanoscience and Nanotechnology, Vol. 16, No. 9, 01.09.2016, p. 9015-9021.

Research output: Contribution to journalArticle

Rana, D, Leena, M, Nithyananth, M, Pasricha, R, Manivasagam, G & Ramalingam, M 2016, 'Control of stem cell fate and function by polymer nanofibers', Journal of Nanoscience and Nanotechnology, vol. 16, no. 9, pp. 9015-9021. https://doi.org/10.1166/jnn.2016.12735
Rana, Deepti ; Leena, Maria ; Nithyananth, Manasseh ; Pasricha, Renu ; Manivasagam, Geetha ; Ramalingam, Murugan. / Control of stem cell fate and function by polymer nanofibers. In: Journal of Nanoscience and Nanotechnology. 2016 ; Vol. 16, No. 9. pp. 9015-9021.
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