Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1

Dino Dvorak, Basma Radwan, Fraser T. Sparks, Zoe Nicole Talbot, Andre Fenton

Research output: Contribution to journalArticle

Abstract

Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During a shocked-place avoidance task, slow gamma (SG) (30–50 Hz) dominates mid-frequency gamma (MG) (70–90 Hz) oscillations 2–3 s before successful avoidance, but not failures. Wild-type (WT) but not Fmr1-null mice rapidly adapt to relocating the shock; concurrently, SG/MG maxima (SGdom) decrease in WT but not in cognitively inflexible Fmr1-null mice. During SGdom, putative pyramidal cell ensembles represent distant locations; during place avoidance, these are avoided places. During shock relocation, WT ensembles represent distant locations near the currently correct shock zone, but Fmr1-null ensembles represent the formerly correct zone. These findings indicate that recollection occurs when CA1 SG dominates MG and that accurate recollection of inappropriate memories explains Fmr1-null cognitive inflexibility.

Original languageEnglish (US)
Article numbere2003354
JournalPLoS Biology
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2018

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hippocampus
Hippocampus
Data storage equipment
Shock
Relocation
mice
Animals
Fragile X Syndrome
oscillation
Pyramidal Cells
Memory Disorders
Proxy
animal models
animals
cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. / Dvorak, Dino; Radwan, Basma; Sparks, Fraser T.; Talbot, Zoe Nicole; Fenton, Andre.

In: PLoS Biology, Vol. 16, No. 1, e2003354, 01.01.2018.

Research output: Contribution to journalArticle

Dvorak, Dino ; Radwan, Basma ; Sparks, Fraser T. ; Talbot, Zoe Nicole ; Fenton, Andre. / Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1. In: PLoS Biology. 2018 ; Vol. 16, No. 1.
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