Control of cell adhesion and growth with micropatterned supported lipid membranes

Jay T. Groves, Lara K. Mahal, Carolyn R. Bertozzi

Research output: Contribution to journalArticle

Abstract

In this work, phospholipid bilayers are employed as biomimetic coating materials to modulate the adhesion and growth of cells on solid substrates. A variety of lipid compositions and charge densities are examined. Culturing cells on these supported membranes reveals that fluid lipid bilayers generally block cell adhesion with a notable exception provided by membranes containing phosphatidylserine, which strongly promote adhesion and growth. This dichotomy is utilized with micropatterned membrane technology to selectively direct cell growth to specified regions on a substrate. Lipid composition in micropatterned membrane arrays is demonstrated to be a simple and effective means of patterning cell growth on surfaces.

Original languageEnglish (US)
Pages (from-to)5129-5133
Number of pages5
JournalLangmuir
Volume17
Issue number17
DOIs
StatePublished - Aug 21 2001

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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