Control of cell adhesion and growth with micropatterned supported lipid membranes

Jay T. Groves, Lara Mahal, Carolyn R. Bertozzi

Research output: Contribution to journalArticle

Abstract

In this work, phospholipid bilayers are employed as biomimetic coating materials to modulate the adhesion and growth of cells on solid substrates. A variety of lipid compositions and charge densities are examined. Culturing cells on these supported membranes reveals that fluid lipid bilayers generally block cell adhesion with a notable exception provided by membranes containing phosphatidylserine, which strongly promote adhesion and growth. This dichotomy is utilized with micropatterned membrane technology to selectively direct cell growth to specified regions on a substrate. Lipid composition in micropatterned membrane arrays is demonstrated to be a simple and effective means of patterning cell growth on surfaces.

Original languageEnglish (US)
Pages (from-to)5129-5133
Number of pages5
JournalLangmuir
Volume17
Issue number17
DOIs
StatePublished - Aug 21 2001

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Cell adhesion
Cell growth
Membrane Lipids
lipids
adhesion
membranes
Membranes
Lipids
Adhesion
cells
Membrane technology
Lipid bilayers
cell culturing
Phosphatidylserines
Phospholipids
Biomimetics
Substrates
Charge density
Chemical analysis
dichotomies

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Control of cell adhesion and growth with micropatterned supported lipid membranes. / Groves, Jay T.; Mahal, Lara; Bertozzi, Carolyn R.

In: Langmuir, Vol. 17, No. 17, 21.08.2001, p. 5129-5133.

Research output: Contribution to journalArticle

Groves, Jay T. ; Mahal, Lara ; Bertozzi, Carolyn R. / Control of cell adhesion and growth with micropatterned supported lipid membranes. In: Langmuir. 2001 ; Vol. 17, No. 17. pp. 5129-5133.
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