Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls

The history of a LINE-1 extinction

Akash Sookdeo, Crystal M. Hepp, Stephane Boissinot

    Research output: Contribution to journalArticle

    Abstract

    Background: LINE-1 (L1) is the dominant autonomously replicating non-LTR retrotransposon in mammals. Although our knowledge of L1 evolution across the tree of life has considerably improved in recent years, what we know of L1 evolution in mammals is biased and comes mostly from studies in primates (mostly human) and rodents (mostly mouse). It is unclear if patterns of evolution that are shared between those two groups apply to other mammalian orders. Here we performed a detailed study on the evolution of L1 in perissodactyls by making use of the complete genome of the domestic horse and of the white rhinoceros. This mammalian order offers an excellent model to study the extinction of L1 since the rhinoceros is one of the few mammalian species to have lost active L1. Results: We found that multiple L1 lineages, carrying different 5'UTRs, have been simultaneously active during the evolution of perissodactyls. We also found that L1 has continuously amplified and diversified in horse. In rhinoceros, L1 was very prolific early on. Two successful families were simultaneously active until ~20my ago but became extinct suddenly at exactly the same time. Conclusions: The general pattern of L1 evolution in perissodactyls is very similar to what was previously described in mouse and human, suggesting some commonalities in the way mammalian genomes interact with L1. We confirmed the extinction of L1 in rhinoceros and we discuss several possible mechanisms.

    Original languageEnglish (US)
    Article number12
    JournalMobile DNA
    Volume9
    Issue number1
    DOIs
    StatePublished - Mar 28 2018

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    Retroelements
    Horses
    Mammals
    History
    Genome
    5' Untranslated Regions
    Primates
    Rodentia

    Keywords

    • Horse
    • LINE-1
    • Molecular evolution
    • Perissodactyla
    • Retrotransposon
    • Rhinoceros

    ASJC Scopus subject areas

    • Molecular Biology

    Cite this

    Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls : The history of a LINE-1 extinction. / Sookdeo, Akash; Hepp, Crystal M.; Boissinot, Stephane.

    In: Mobile DNA, Vol. 9, No. 1, 12, 28.03.2018.

    Research output: Contribution to journalArticle

    Sookdeo, Akash ; Hepp, Crystal M. ; Boissinot, Stephane. / Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls : The history of a LINE-1 extinction. In: Mobile DNA. 2018 ; Vol. 9, No. 1.
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