Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning

Masayuki Sakamoto, Nao Ieki, Goichi Miyoshi, Daisuke Mochimaru, Hitoshi Miyachi, Tetsuya Imura, Masahiro Yamaguchi, Gordon Fishell, Kensaku Mori, Ryoichiro Kageyama, Itaru Imayoshi

Research output: Contribution to journalArticle

Abstract

The olfactory bulb (OB) is one of the two major loci in the mammalian brain where newborn neurons are constantly integrated into the neural circuit during postnatal life. Newborn neurons are generated from neural stem cells in the subventricular zone (SVZ) of the lateral ventricle and migrate to the OB through the rostral migratory stream. The majority of these newborn neurons differentiate into inhibitory interneurons, such as granule cells and periglomerular cells. It has been reported that prolonged supply of newborn neurons leads to continuous addition/turnover of the interneuronal populations and contributes to functional integrity of the OB circuit. However, it is not still clear how and to what extent postnatal-born neurons contribute to OB neural circuit formation, and the functional role of postnatal neurogenesis in odor-related behaviors remains elusive. To address this question, here by using genetic strategies, we first determined the unique integration mode of newly born interneurons during postnatal development of the mouse OB. We then manipulated these interneuron populations and found that continuous postnatal neurogenesis in the SVZ-OB plays pivotal roles in flexible olfactory associative learning and memory.

Original languageEnglish (US)
Pages (from-to)5788-5799
Number of pages12
JournalJournal of Neuroscience
Volume34
Issue number17
DOIs
StatePublished - Jan 1 2014

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Olfactory Bulb
Neurogenesis
Learning
Lateral Ventricles
Neurons
Interneurons
Neural Stem Cells
Population
Brain

Keywords

  • Dentate gyrus
  • Hippocampus
  • Learning
  • Neural stem cells
  • Neurogenesis
  • Olfactory bulb

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. / Sakamoto, Masayuki; Ieki, Nao; Miyoshi, Goichi; Mochimaru, Daisuke; Miyachi, Hitoshi; Imura, Tetsuya; Yamaguchi, Masahiro; Fishell, Gordon; Mori, Kensaku; Kageyama, Ryoichiro; Imayoshi, Itaru.

In: Journal of Neuroscience, Vol. 34, No. 17, 01.01.2014, p. 5788-5799.

Research output: Contribution to journalArticle

Sakamoto, M, Ieki, N, Miyoshi, G, Mochimaru, D, Miyachi, H, Imura, T, Yamaguchi, M, Fishell, G, Mori, K, Kageyama, R & Imayoshi, I 2014, 'Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning', Journal of Neuroscience, vol. 34, no. 17, pp. 5788-5799. https://doi.org/10.1523/JNEUROSCI.0674-14.2014
Sakamoto, Masayuki ; Ieki, Nao ; Miyoshi, Goichi ; Mochimaru, Daisuke ; Miyachi, Hitoshi ; Imura, Tetsuya ; Yamaguchi, Masahiro ; Fishell, Gordon ; Mori, Kensaku ; Kageyama, Ryoichiro ; Imayoshi, Itaru. / Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 17. pp. 5788-5799.
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