Continuity and Change Within an HIV Epidemic: Injecting Drug Users in New York City, 1984 Through 1992

Don Des Jarlais, Samuel R. Friedman, J. L. Sotheran, John Wenston, Michael Marmor, Stanley R. Yancovitz, Blanche Frank, Sara Beatrice, Donna Mildvan

Research output: Contribution to journalArticle

Abstract

To examine trends in acquired immunodeficiency syndrome (AIDS) risk behavior and human immunodeficiency virus (HIV) seroprevalence among injecting drug users (IDUs) in New York City from 1984 through 1992. —Comparisons were made between two surveys of IDUs at the same hospital-based New York City drug abuse detoxification program: 141 IDUs in 1984 and 974 IDUs in 1990 through 1992. National Death Registry, New York City Health Department, and drug treatment program records were also used. —Persons attending detoxification program randomly selected for participation. Eligibility was based on injection within previous 2 months; 99% acceptance rates were obtained. Participants in the 1984 and 1990 through 1992 surveys were 66% and 79% men, 21% and 19% white, 33% and 34% African American, and 45% and 46% Latin American, respectively. —Community-based AIDS prevention programs, including underground syringe exchanges. —Acquired immunodeficiency syndrome risk behaviors; HIV serostatus; CD4+ cell counts; death rates among 1984 subjects; and injection and intranasal routes of drug administration. —The HIV seroprevalence remained stable at slightly more than 50%. Mean CD4+ cell counts declined from 0.716×109/L (716/μL) to 0.575×109/L (P<.009). Annual death rate among 1984 subjects was 3%, with a significantly higher rate among HIV-seropositive subjects (relative risk, 2.57; 95% exact binomial confidence interval, 1.12 to 6.61). Large-scale declines were observed in AIDS risk behaviors, eg, use of potentially contaminated syringes declined from 51% to 7% of injections (P<.001). Recent additional risk reduction was associated with use of the underground syringe exchanges. Intranasal heroin use was the primary route of drug administration for 46% of heroin admissions to New York City drug treatment programs. —The HIV seroprevalence has remained stable among this population of New York City IDUs for almost a decade. Continuation of current trends should lead to further reduction in HIV transmission, although reversal of the trend to intranasal use could lead to substantially increased transmission.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Volume271
Issue number2
DOIs
StatePublished - Jan 12 1994

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Drug Users
HIV
Seroepidemiologic Studies
Syringes
Acquired Immunodeficiency Syndrome
Risk-Taking
Heroin
CD4 Lymphocyte Count
Injections
Drug Administration Routes
Intranasal Administration
Mortality
Population Dynamics
Risk Reduction Behavior
Pharmaceutical Preparations
African Americans
Substance-Related Disorders
Registries
Confidence Intervals
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Continuity and Change Within an HIV Epidemic : Injecting Drug Users in New York City, 1984 Through 1992. / Des Jarlais, Don; Friedman, Samuel R.; Sotheran, J. L.; Wenston, John; Marmor, Michael; Yancovitz, Stanley R.; Frank, Blanche; Beatrice, Sara; Mildvan, Donna.

In: JAMA: The Journal of the American Medical Association, Vol. 271, No. 2, 12.01.1994, p. 121-127.

Research output: Contribution to journalArticle

Des Jarlais, D, Friedman, SR, Sotheran, JL, Wenston, J, Marmor, M, Yancovitz, SR, Frank, B, Beatrice, S & Mildvan, D 1994, 'Continuity and Change Within an HIV Epidemic: Injecting Drug Users in New York City, 1984 Through 1992', JAMA: The Journal of the American Medical Association, vol. 271, no. 2, pp. 121-127. https://doi.org/10.1001/jama.1994.03510260053028
Des Jarlais, Don ; Friedman, Samuel R. ; Sotheran, J. L. ; Wenston, John ; Marmor, Michael ; Yancovitz, Stanley R. ; Frank, Blanche ; Beatrice, Sara ; Mildvan, Donna. / Continuity and Change Within an HIV Epidemic : Injecting Drug Users in New York City, 1984 Through 1992. In: JAMA: The Journal of the American Medical Association. 1994 ; Vol. 271, No. 2. pp. 121-127.
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