Abstract
Although the medial temporal lobe (MTL) is known to be essential for episodic encoding, the contributions of individual MTL subregions remain unclear. Data from recognition memory studies have provided evidence that the hippocampus supports relational encoding important for later episodic recollection, whereas the perirhinal cortex has been linked with encoding that supports later item familiarity. However, extant data also strongly implicate the perirhinal cortex in object processing and encoding, suggesting that perirhinal processes may contribute to later episodic recollection of object source details. To investigate this possibility, encoding activation in MTL subregions was analyzed on the basis of subsequent memory outcome while participants processed novel scenes paired with 1 of 6 repeating objects. Specifically, encoding activation correlating with later successful scene recognition memory was evaluated against that of source recollection for the object paired with the scene during encoding. In contrast to studies reporting a link between perirhinal cortex and item familiarity, it was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object. Furthermore, other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 769-779 |
| Number of pages | 11 |
| Journal | Journal of Experimental Psychology: Learning Memory and Cognition |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2008 |
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Keywords
- domain specificity
- fMRI
- medial temporal lobe
- perirhinal cortex
- recollection
ASJC Scopus subject areas
- Psychology(all)
Cite this
Content-Specific Source Encoding in the Human Medial Temporal Lobe. / Awipi, T.; Davachi, L.
In: Journal of Experimental Psychology: Learning Memory and Cognition, Vol. 34, No. 4, 07.2008, p. 769-779.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Content-Specific Source Encoding in the Human Medial Temporal Lobe
AU - Awipi, T.
AU - Davachi, L.
PY - 2008/7
Y1 - 2008/7
N2 - Although the medial temporal lobe (MTL) is known to be essential for episodic encoding, the contributions of individual MTL subregions remain unclear. Data from recognition memory studies have provided evidence that the hippocampus supports relational encoding important for later episodic recollection, whereas the perirhinal cortex has been linked with encoding that supports later item familiarity. However, extant data also strongly implicate the perirhinal cortex in object processing and encoding, suggesting that perirhinal processes may contribute to later episodic recollection of object source details. To investigate this possibility, encoding activation in MTL subregions was analyzed on the basis of subsequent memory outcome while participants processed novel scenes paired with 1 of 6 repeating objects. Specifically, encoding activation correlating with later successful scene recognition memory was evaluated against that of source recollection for the object paired with the scene during encoding. In contrast to studies reporting a link between perirhinal cortex and item familiarity, it was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object. Furthermore, other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.
AB - Although the medial temporal lobe (MTL) is known to be essential for episodic encoding, the contributions of individual MTL subregions remain unclear. Data from recognition memory studies have provided evidence that the hippocampus supports relational encoding important for later episodic recollection, whereas the perirhinal cortex has been linked with encoding that supports later item familiarity. However, extant data also strongly implicate the perirhinal cortex in object processing and encoding, suggesting that perirhinal processes may contribute to later episodic recollection of object source details. To investigate this possibility, encoding activation in MTL subregions was analyzed on the basis of subsequent memory outcome while participants processed novel scenes paired with 1 of 6 repeating objects. Specifically, encoding activation correlating with later successful scene recognition memory was evaluated against that of source recollection for the object paired with the scene during encoding. In contrast to studies reporting a link between perirhinal cortex and item familiarity, it was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object. Furthermore, other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.
KW - domain specificity
KW - fMRI
KW - medial temporal lobe
KW - perirhinal cortex
KW - recollection
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U2 - 10.1037/0278-7393.34.4.769
DO - 10.1037/0278-7393.34.4.769
M3 - Article
VL - 34
SP - 769
EP - 779
JO - Journal of Experimental Psychology: Learning Memory and Cognition
JF - Journal of Experimental Psychology: Learning Memory and Cognition
SN - 0278-7393
IS - 4
ER -