Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh

Julia E. Heck, Mary V. Gamble, Yu Chen, Joseph H. Graziano, Vesna Slavkovich, Faruque Parvez, John A. Baron, Geoffrey R. Howe, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

Background: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes. Objective: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. Design: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles. Results: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (β = 0.22, P = 0.02) and choline (β = 0.10, P = 0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake. Conclusions: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.

Original languageEnglish (US)
Pages (from-to)1367-1374
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume85
Issue number5
StatePublished - May 1 2007

Fingerprint

Bangladesh
Arsenic
Folic Acid
Food
Cacodylic Acid
Methylation
Niacin
Vitamin B 12
Methionine
Cysteine
Multivariate Analysis
Urine
Health
Choline
Energy Intake
Drinking Water
Smoking
Regression Analysis

Keywords

  • Arsenic
  • Bangladesh
  • Choline
  • Cysteine
  • Folate
  • Methionine
  • Methylation
  • Nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Heck, J. E., Gamble, M. V., Chen, Y., Graziano, J. H., Slavkovich, V., Parvez, F., ... Ahsan, H. (2007). Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh. American Journal of Clinical Nutrition, 85(5), 1367-1374.

Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh. / Heck, Julia E.; Gamble, Mary V.; Chen, Yu; Graziano, Joseph H.; Slavkovich, Vesna; Parvez, Faruque; Baron, John A.; Howe, Geoffrey R.; Ahsan, Habibul.

In: American Journal of Clinical Nutrition, Vol. 85, No. 5, 01.05.2007, p. 1367-1374.

Research output: Contribution to journalArticle

Heck, JE, Gamble, MV, Chen, Y, Graziano, JH, Slavkovich, V, Parvez, F, Baron, JA, Howe, GR & Ahsan, H 2007, 'Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh', American Journal of Clinical Nutrition, vol. 85, no. 5, pp. 1367-1374.
Heck JE, Gamble MV, Chen Y, Graziano JH, Slavkovich V, Parvez F et al. Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh. American Journal of Clinical Nutrition. 2007 May 1;85(5):1367-1374.
Heck, Julia E. ; Gamble, Mary V. ; Chen, Yu ; Graziano, Joseph H. ; Slavkovich, Vesna ; Parvez, Faruque ; Baron, John A. ; Howe, Geoffrey R. ; Ahsan, Habibul. / Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh. In: American Journal of Clinical Nutrition. 2007 ; Vol. 85, No. 5. pp. 1367-1374.
@article{b50958f768b74fd98e30157f26a78394,
title = "Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh",
abstract = "Background: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes. Objective: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. Design: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles. Results: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (β = 0.22, P = 0.02) and choline (β = 0.10, P = 0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake. Conclusions: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.",
keywords = "Arsenic, Bangladesh, Choline, Cysteine, Folate, Methionine, Methylation, Nutrition",
author = "Heck, {Julia E.} and Gamble, {Mary V.} and Yu Chen and Graziano, {Joseph H.} and Vesna Slavkovich and Faruque Parvez and Baron, {John A.} and Howe, {Geoffrey R.} and Habibul Ahsan",
year = "2007",
month = "5",
day = "1",
language = "English (US)",
volume = "85",
pages = "1367--1374",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh

AU - Heck, Julia E.

AU - Gamble, Mary V.

AU - Chen, Yu

AU - Graziano, Joseph H.

AU - Slavkovich, Vesna

AU - Parvez, Faruque

AU - Baron, John A.

AU - Howe, Geoffrey R.

AU - Ahsan, Habibul

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Background: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes. Objective: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. Design: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles. Results: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (β = 0.22, P = 0.02) and choline (β = 0.10, P = 0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake. Conclusions: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.

AB - Background: Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes. Objective: The purpose of this study was to examine whether the capacity to methylate arsenic differs by nutrient intake. Design: Participants were 1016 Bangladeshi adults exposed to arsenic in drinking water. Nutrient intake was assessed with a validated food-frequency questionnaire. Multivariate regression analyses were used to examine associations of nutrients with urinary arsenic metabolite profiles. Results: In multivariate analyses, higher intakes of cysteine, methionine, calcium, protein, and vitamin B-12 were associated with lower percentages of InAs and higher ratios of MMA to InAs in urine. Higher intakes of niacin (β = 0.22, P = 0.02) and choline (β = 0.10, P = 0.02) were associated with higher DMA-to-MMA ratios, after adjustment for age, sex, smoking, total urinary arsenic, and total energy intake. Conclusions: Findings from the current study show the influence of multiple nutrients on arsenic methylation. In particular, this study highlights the potential importance of dietary intakes of cysteine, methionine, niacin, vitamin B-12, and choline on health effects of arsenic by modulating its metabolism.

KW - Arsenic

KW - Bangladesh

KW - Choline

KW - Cysteine

KW - Folate

KW - Methionine

KW - Methylation

KW - Nutrition

UR - http://www.scopus.com/inward/record.url?scp=34248337901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248337901&partnerID=8YFLogxK

M3 - Article

C2 - 17490975

AN - SCOPUS:34248337901

VL - 85

SP - 1367

EP - 1374

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -