Construction of three-dimensional stick figures from branched DNA

Research output: Contribution to journalArticle

Abstract

Stable DNA branched junction molecules can be used as the building blocks for stick-figures in which the edges are double-helical DNA and the vertices correspond to the branch points of the junctions. Sticky-ended cohesion is used to direct the association of individual branched complexes. The sequences of these molecules are assigned by a sequence-symmetry minimization procedure. Successful ligation experiments include the oligomerization of individual three-arm and four-arm junctions, the assembly of a quadrilateral from four junctions with different sticky ends, and the recent construction of a molecule with the connectivity of a cube. Possible applications include the assembly of molecular electronic devices, the formation of macromolecular-scale zeolites to host biological complexes for diffraction analysis, and the development of new catalysts.

Original languageEnglish (US)
Pages (from-to)475-486
Number of pages12
JournalDNA and Cell Biology
Volume10
Issue number7
StatePublished - 1991

Fingerprint

Zeolites
DNA
Ligation
Equipment and Supplies

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Construction of three-dimensional stick figures from branched DNA. / Seeman, Nadrian.

In: DNA and Cell Biology, Vol. 10, No. 7, 1991, p. 475-486.

Research output: Contribution to journalArticle

@article{86630558eaf240e3ac48f4176edb42f3,
title = "Construction of three-dimensional stick figures from branched DNA",
abstract = "Stable DNA branched junction molecules can be used as the building blocks for stick-figures in which the edges are double-helical DNA and the vertices correspond to the branch points of the junctions. Sticky-ended cohesion is used to direct the association of individual branched complexes. The sequences of these molecules are assigned by a sequence-symmetry minimization procedure. Successful ligation experiments include the oligomerization of individual three-arm and four-arm junctions, the assembly of a quadrilateral from four junctions with different sticky ends, and the recent construction of a molecule with the connectivity of a cube. Possible applications include the assembly of molecular electronic devices, the formation of macromolecular-scale zeolites to host biological complexes for diffraction analysis, and the development of new catalysts.",
author = "Nadrian Seeman",
year = "1991",
language = "English (US)",
volume = "10",
pages = "475--486",
journal = "DNA and Cell Biology",
issn = "1044-5498",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Construction of three-dimensional stick figures from branched DNA

AU - Seeman, Nadrian

PY - 1991

Y1 - 1991

N2 - Stable DNA branched junction molecules can be used as the building blocks for stick-figures in which the edges are double-helical DNA and the vertices correspond to the branch points of the junctions. Sticky-ended cohesion is used to direct the association of individual branched complexes. The sequences of these molecules are assigned by a sequence-symmetry minimization procedure. Successful ligation experiments include the oligomerization of individual three-arm and four-arm junctions, the assembly of a quadrilateral from four junctions with different sticky ends, and the recent construction of a molecule with the connectivity of a cube. Possible applications include the assembly of molecular electronic devices, the formation of macromolecular-scale zeolites to host biological complexes for diffraction analysis, and the development of new catalysts.

AB - Stable DNA branched junction molecules can be used as the building blocks for stick-figures in which the edges are double-helical DNA and the vertices correspond to the branch points of the junctions. Sticky-ended cohesion is used to direct the association of individual branched complexes. The sequences of these molecules are assigned by a sequence-symmetry minimization procedure. Successful ligation experiments include the oligomerization of individual three-arm and four-arm junctions, the assembly of a quadrilateral from four junctions with different sticky ends, and the recent construction of a molecule with the connectivity of a cube. Possible applications include the assembly of molecular electronic devices, the formation of macromolecular-scale zeolites to host biological complexes for diffraction analysis, and the development of new catalysts.

UR - http://www.scopus.com/inward/record.url?scp=0025900334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025900334&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 475

EP - 486

JO - DNA and Cell Biology

JF - DNA and Cell Biology

SN - 1044-5498

IS - 7

ER -