Construction of a well-defined multifunctional dendrimer for theranostics

Cátia Ornelas, Ryan Pennell, Leonard F. Liebes, Marcus Weck

Research output: Contribution to journalArticle

Abstract

A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty-four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described here might be promising for fabricating the next generation of materials for theranostics.(Figure Presented)

Original languageEnglish (US)
Pages (from-to)976-979
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
StatePublished - Mar 4 2011

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Dendrimers
dendrimers
Infrared radiation
Azides
Nylons
toxicity
Amines
Toxicity
amines
Coloring Agents
Fluorescence
dyes
Cells
fluorescence
acids
Acids
Theranostic Nanomedicine

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Construction of a well-defined multifunctional dendrimer for theranostics. / Ornelas, Cátia; Pennell, Ryan; Liebes, Leonard F.; Weck, Marcus.

In: Organic Letters, Vol. 13, No. 5, 04.03.2011, p. 976-979.

Research output: Contribution to journalArticle

Ornelas, Cátia ; Pennell, Ryan ; Liebes, Leonard F. ; Weck, Marcus. / Construction of a well-defined multifunctional dendrimer for theranostics. In: Organic Letters. 2011 ; Vol. 13, No. 5. pp. 976-979.
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