Conserved fMRI and LFP Signals during New Associative Learning in the Human and Macaque Monkey Medial Temporal Lobe

Eric L. Hargreaves, Aaron T. Mattfeld, Craig E L Stark, Wendy Suzuki

Research output: Contribution to journalArticle

Abstract

We measured local field potential (LFP) and blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in the medial temporal lobes of monkeys and humans, respectively, as they performed the same conditional motor associative learning task. Parallel analyses were used to examine both data sets. Despite significantly faster learning in humans relative to monkeys, we found equivalent neural signals differentiating new versus highly familiar stimuli, first stimulus presentation, trial outcome, and learning strength in the entorhinal cortex and hippocampus of both species. Thus, the use of parallel behavioral tasks and analyses in monkeys and humans revealed conserved patterns of neural activity across the medial temporal lobe during an associative learning task.

Original languageEnglish (US)
Pages (from-to)743-752
Number of pages10
JournalNeuron
Volume74
Issue number4
DOIs
StatePublished - May 24 2012

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Macaca
Temporal Lobe
Haplorhini
Magnetic Resonance Imaging
Learning
Entorhinal Cortex
Hippocampus
Oxygen

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Conserved fMRI and LFP Signals during New Associative Learning in the Human and Macaque Monkey Medial Temporal Lobe. / Hargreaves, Eric L.; Mattfeld, Aaron T.; Stark, Craig E L; Suzuki, Wendy.

In: Neuron, Vol. 74, No. 4, 24.05.2012, p. 743-752.

Research output: Contribution to journalArticle

Hargreaves, Eric L. ; Mattfeld, Aaron T. ; Stark, Craig E L ; Suzuki, Wendy. / Conserved fMRI and LFP Signals during New Associative Learning in the Human and Macaque Monkey Medial Temporal Lobe. In: Neuron. 2012 ; Vol. 74, No. 4. pp. 743-752.
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