Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state

Susanne Balazs, Christoph Stepan, Heinrich Binder, Hans von Gizycki, Matt Avitable, Armin Obersteiner, Frank Rattay, Ivan Selesnick, Ivan Bodis-Wollner

Research output: Contribution to journalArticle

Abstract

Background: Power in the gamma band EEG increases during saccades in normal subjects. Objective: To develop a potential method to quantify signs of cortical responsiveness in persistent vegetative state (PVS) we quantified gamma range EEG in association with conjugate slow ballistic eye movements (SBEM). Methods: The EEG and the simultaneous electro-oculogram were recorded in 14 (8F/6M) PVS patients. Clinical scoring was based on the Glasgow Coma Scale (GCS) and Coma Rating Scale (CRS). The Wavelet Transform, followed by Hilbert transform was applied to the EEG and gamma power distribution was quantified relative to the timing of an eye movement. We correlated the clinical and the neurophysiological measures. Results: Gamma activity was present in all PVS patients. Its power was modulated in association with eye movements only in less severely affected patients, with minimum power prior to, and maximum power during the eye movement. In severely affected patients there was no evidence of a temporal relationship between gamma power and the phase of the eye movement. Conclusions: Detecting changes in the time course of gamma power in relation to conjugate ballistic eye movements provides a quantitative neurophysiological method for prospective longitudinal studies to explore if the preservation of this CNS function relates to the potential for recovery in PVS patients.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalJournal of the Neurological Sciences
Volume246
Issue number1-2
DOIs
StatePublished - Jul 15 2006

Fingerprint

Persistent Vegetative State
Eye Movements
Electroencephalography
Wavelet Analysis
Glasgow Coma Scale
Saccades
Coma
Longitudinal Studies
Prospective Studies

Keywords

  • Coma
  • Conjugate eye movements in PVS
  • Gamma and coma
  • Neurorehabilitation
  • Persistent vegetative state (PVS)
  • Wavelet transformed EEG

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Balazs, S., Stepan, C., Binder, H., von Gizycki, H., Avitable, M., Obersteiner, A., ... Bodis-Wollner, I. (2006). Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state. Journal of the Neurological Sciences, 246(1-2), 65-69. https://doi.org/10.1016/j.jns.2006.02.007

Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state. / Balazs, Susanne; Stepan, Christoph; Binder, Heinrich; von Gizycki, Hans; Avitable, Matt; Obersteiner, Armin; Rattay, Frank; Selesnick, Ivan; Bodis-Wollner, Ivan.

In: Journal of the Neurological Sciences, Vol. 246, No. 1-2, 15.07.2006, p. 65-69.

Research output: Contribution to journalArticle

Balazs, S, Stepan, C, Binder, H, von Gizycki, H, Avitable, M, Obersteiner, A, Rattay, F, Selesnick, I & Bodis-Wollner, I 2006, 'Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state', Journal of the Neurological Sciences, vol. 246, no. 1-2, pp. 65-69. https://doi.org/10.1016/j.jns.2006.02.007
Balazs, Susanne ; Stepan, Christoph ; Binder, Heinrich ; von Gizycki, Hans ; Avitable, Matt ; Obersteiner, Armin ; Rattay, Frank ; Selesnick, Ivan ; Bodis-Wollner, Ivan. / Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state. In: Journal of the Neurological Sciences. 2006 ; Vol. 246, No. 1-2. pp. 65-69.
@article{e53485cb86124383a31beaac85d7251b,
title = "Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state",
abstract = "Background: Power in the gamma band EEG increases during saccades in normal subjects. Objective: To develop a potential method to quantify signs of cortical responsiveness in persistent vegetative state (PVS) we quantified gamma range EEG in association with conjugate slow ballistic eye movements (SBEM). Methods: The EEG and the simultaneous electro-oculogram were recorded in 14 (8F/6M) PVS patients. Clinical scoring was based on the Glasgow Coma Scale (GCS) and Coma Rating Scale (CRS). The Wavelet Transform, followed by Hilbert transform was applied to the EEG and gamma power distribution was quantified relative to the timing of an eye movement. We correlated the clinical and the neurophysiological measures. Results: Gamma activity was present in all PVS patients. Its power was modulated in association with eye movements only in less severely affected patients, with minimum power prior to, and maximum power during the eye movement. In severely affected patients there was no evidence of a temporal relationship between gamma power and the phase of the eye movement. Conclusions: Detecting changes in the time course of gamma power in relation to conjugate ballistic eye movements provides a quantitative neurophysiological method for prospective longitudinal studies to explore if the preservation of this CNS function relates to the potential for recovery in PVS patients.",
keywords = "Coma, Conjugate eye movements in PVS, Gamma and coma, Neurorehabilitation, Persistent vegetative state (PVS), Wavelet transformed EEG",
author = "Susanne Balazs and Christoph Stepan and Heinrich Binder and {von Gizycki}, Hans and Matt Avitable and Armin Obersteiner and Frank Rattay and Ivan Selesnick and Ivan Bodis-Wollner",
year = "2006",
month = "7",
day = "15",
doi = "10.1016/j.jns.2006.02.007",
language = "English (US)",
volume = "246",
pages = "65--69",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative state

AU - Balazs, Susanne

AU - Stepan, Christoph

AU - Binder, Heinrich

AU - von Gizycki, Hans

AU - Avitable, Matt

AU - Obersteiner, Armin

AU - Rattay, Frank

AU - Selesnick, Ivan

AU - Bodis-Wollner, Ivan

PY - 2006/7/15

Y1 - 2006/7/15

N2 - Background: Power in the gamma band EEG increases during saccades in normal subjects. Objective: To develop a potential method to quantify signs of cortical responsiveness in persistent vegetative state (PVS) we quantified gamma range EEG in association with conjugate slow ballistic eye movements (SBEM). Methods: The EEG and the simultaneous electro-oculogram were recorded in 14 (8F/6M) PVS patients. Clinical scoring was based on the Glasgow Coma Scale (GCS) and Coma Rating Scale (CRS). The Wavelet Transform, followed by Hilbert transform was applied to the EEG and gamma power distribution was quantified relative to the timing of an eye movement. We correlated the clinical and the neurophysiological measures. Results: Gamma activity was present in all PVS patients. Its power was modulated in association with eye movements only in less severely affected patients, with minimum power prior to, and maximum power during the eye movement. In severely affected patients there was no evidence of a temporal relationship between gamma power and the phase of the eye movement. Conclusions: Detecting changes in the time course of gamma power in relation to conjugate ballistic eye movements provides a quantitative neurophysiological method for prospective longitudinal studies to explore if the preservation of this CNS function relates to the potential for recovery in PVS patients.

AB - Background: Power in the gamma band EEG increases during saccades in normal subjects. Objective: To develop a potential method to quantify signs of cortical responsiveness in persistent vegetative state (PVS) we quantified gamma range EEG in association with conjugate slow ballistic eye movements (SBEM). Methods: The EEG and the simultaneous electro-oculogram were recorded in 14 (8F/6M) PVS patients. Clinical scoring was based on the Glasgow Coma Scale (GCS) and Coma Rating Scale (CRS). The Wavelet Transform, followed by Hilbert transform was applied to the EEG and gamma power distribution was quantified relative to the timing of an eye movement. We correlated the clinical and the neurophysiological measures. Results: Gamma activity was present in all PVS patients. Its power was modulated in association with eye movements only in less severely affected patients, with minimum power prior to, and maximum power during the eye movement. In severely affected patients there was no evidence of a temporal relationship between gamma power and the phase of the eye movement. Conclusions: Detecting changes in the time course of gamma power in relation to conjugate ballistic eye movements provides a quantitative neurophysiological method for prospective longitudinal studies to explore if the preservation of this CNS function relates to the potential for recovery in PVS patients.

KW - Coma

KW - Conjugate eye movements in PVS

KW - Gamma and coma

KW - Neurorehabilitation

KW - Persistent vegetative state (PVS)

KW - Wavelet transformed EEG

UR - http://www.scopus.com/inward/record.url?scp=33744510652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744510652&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2006.02.007

DO - 10.1016/j.jns.2006.02.007

M3 - Article

C2 - 16580696

AN - SCOPUS:33744510652

VL - 246

SP - 65

EP - 69

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -