Conformational change and denaturation of proteins by cyclic silicone

L. Sun, H. Alexander, N. Lattarulo, N. C. Blumenthal, John Ricci, G. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An important aspect of the immunological response to silicon implants is the interaction between low-molecular-weight silicones, like cyclic silicones, and protein molecules. Fibrinogen and fibronectin were incubated with the cyclic silicone octamethylcyclotetrasiloxane (D 4) with stirring under normal conditions for up to 8 hours. The effect of D 4 on both proteins were investigated by fluorescence and circular dichroism spectroscopy. The study indicated that cyclic silicone induces conformational change and denaturation in fibrinogen and fibronectin, common proteins in human plasma and tissue.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
PublisherSoc for Biomaterials
Pages826
Number of pages1
Volume2
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Denaturation
Silicones
Proteins
Fibronectins
Fibrinogen
Circular dichroism spectroscopy
Plasma (human)
Fluorescence
Molecular weight
Tissue
Molecules

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Sun, L., Alexander, H., Lattarulo, N., Blumenthal, N. C., Ricci, J., & Chen, G. (1996). Conformational change and denaturation of proteins by cyclic silicone. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 2, pp. 826). Soc for Biomaterials.

Conformational change and denaturation of proteins by cyclic silicone. / Sun, L.; Alexander, H.; Lattarulo, N.; Blumenthal, N. C.; Ricci, John; Chen, G.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 2 Soc for Biomaterials, 1996. p. 826.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sun, L, Alexander, H, Lattarulo, N, Blumenthal, NC, Ricci, J & Chen, G 1996, Conformational change and denaturation of proteins by cyclic silicone. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 2, Soc for Biomaterials, pp. 826, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.
Sun L, Alexander H, Lattarulo N, Blumenthal NC, Ricci J, Chen G. Conformational change and denaturation of proteins by cyclic silicone. In Anon, editor, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 2. Soc for Biomaterials. 1996. p. 826
Sun, L. ; Alexander, H. ; Lattarulo, N. ; Blumenthal, N. C. ; Ricci, John ; Chen, G. / Conformational change and denaturation of proteins by cyclic silicone. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. editor / Anon. Vol. 2 Soc for Biomaterials, 1996. pp. 826
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