Condensin action and compaction

Matthew Robert Paul, Andreas Hochwagen, Sevinc Ercan

Research output: Contribution to journalArticle

Abstract

Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

Original languageEnglish (US)
JournalCurrent Genetics
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Chromosomes
Genes
Chromosome Structures
Chromosome Segregation
Protein Subunits
Transfer RNA
Ribosomal DNA
DNA Repair
Genetic Recombination
Cluster Analysis
Maintenance
condensin complexes
Phenotype
Research

Keywords

  • Chromosome interactions
  • Chromosome segregation
  • Clustering
  • Condensin
  • gene expression
  • Genome organization
  • rDNA
  • SMCcomplexes
  • TADs
  • Transcription
  • tRNA

ASJC Scopus subject areas

  • Genetics

Cite this

Condensin action and compaction. / Paul, Matthew Robert; Hochwagen, Andreas; Ercan, Sevinc.

In: Current Genetics, 01.01.2018.

Research output: Contribution to journalArticle

@article{09dc8840200a4f4c8e307852901e6538,
title = "Condensin action and compaction",
abstract = "Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.",
keywords = "Chromosome interactions, Chromosome segregation, Clustering, Condensin, gene expression, Genome organization, rDNA, SMCcomplexes, TADs, Transcription, tRNA",
author = "Paul, {Matthew Robert} and Andreas Hochwagen and Sevinc Ercan",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s00294-018-0899-4",
language = "English (US)",
journal = "Current Genetics",
issn = "0172-8083",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Condensin action and compaction

AU - Paul, Matthew Robert

AU - Hochwagen, Andreas

AU - Ercan, Sevinc

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

AB - Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

KW - Chromosome interactions

KW - Chromosome segregation

KW - Clustering

KW - Condensin

KW - gene expression

KW - Genome organization

KW - rDNA

KW - SMCcomplexes

KW - TADs

KW - Transcription

KW - tRNA

UR - http://www.scopus.com/inward/record.url?scp=85055686791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055686791&partnerID=8YFLogxK

U2 - 10.1007/s00294-018-0899-4

DO - 10.1007/s00294-018-0899-4

M3 - Article

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

ER -