Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI

Jae Seung Lee, Ding Xia, Yulin Ge, Alexej Jerschow, Ravinder R. Regatte

Research output: Contribution to journalArticle

Abstract

The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalNeuroImage
Volume95
DOIs
StatePublished - 2014

Fingerprint

Brain
Nervous System Diseases
Neurodegenerative Diseases
Multiple Sclerosis
Healthy Volunteers
Biomarkers
White Matter
Gray Matter

Keywords

  • Chemical exchange saturation transfer
  • Magnetization transfer
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI. / Lee, Jae Seung; Xia, Ding; Ge, Yulin; Jerschow, Alexej; Regatte, Ravinder R.

In: NeuroImage, Vol. 95, 2014, p. 22-28.

Research output: Contribution to journalArticle

Lee, Jae Seung ; Xia, Ding ; Ge, Yulin ; Jerschow, Alexej ; Regatte, Ravinder R. / Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI. In: NeuroImage. 2014 ; Vol. 95. pp. 22-28.
@article{352a8fd05685480c8c3dcff274e1c7d0,
title = "Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI",
abstract = "The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.",
keywords = "Chemical exchange saturation transfer, Magnetization transfer, MRI, Multiple sclerosis",
author = "Lee, {Jae Seung} and Ding Xia and Yulin Ge and Alexej Jerschow and Regatte, {Ravinder R.}",
year = "2014",
doi = "10.1016/j.neuroimage.2014.03.040",
language = "English (US)",
volume = "95",
pages = "22--28",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Concurrent saturation transfer contrast in in vivo brain by a uniform magnetization transfer MRI

AU - Lee, Jae Seung

AU - Xia, Ding

AU - Ge, Yulin

AU - Jerschow, Alexej

AU - Regatte, Ravinder R.

PY - 2014

Y1 - 2014

N2 - The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.

AB - The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI has enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast mechanisms. We demonstrate here that MT and CEST contrast can be separated in the brain by the so-called uniform-MT (uMT) technique, thus opening the door to addressing long-standing ambiguities in this field. These methods could be useful for keeping track of important endogenous metabolites and for providing an improved understanding of neurological and neurodegenerative disorders. Examples are shown from white and gray matter regions in healthy volunteers and patients with multiple sclerosis, which demonstrated that the MT effects in the brain were asymmetric and that the uMT method could make them uniform.

KW - Chemical exchange saturation transfer

KW - Magnetization transfer

KW - MRI

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=84899840078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899840078&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2014.03.040

DO - 10.1016/j.neuroimage.2014.03.040

M3 - Article

C2 - 24662575

AN - SCOPUS:84899840078

VL - 95

SP - 22

EP - 28

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -