Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

Erica M. Wilson, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

Original languageEnglish (US)
Pages (from-to)1327-1329
Number of pages3
JournalOrganic Letters
Volume9
Issue number7
DOIs
StatePublished - Mar 29 2007

Fingerprint

Allylation
DNA Primase
Bacterial DNA
metathesis
closing
inhibitors
deoxyribonucleic acid
rings
synthesis
Sch 642305

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305. / Wilson, Erica M.; Trauner, Dirk.

In: Organic Letters, Vol. 9, No. 7, 29.03.2007, p. 1327-1329.

Research output: Contribution to journalArticle

Wilson, Erica M. ; Trauner, Dirk. / Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305. In: Organic Letters. 2007 ; Vol. 9, No. 7. pp. 1327-1329.
@article{251cfe08638848b98b8ac33606bbd25e,
title = "Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305",
abstract = "Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.",
author = "Wilson, {Erica M.} and Dirk Trauner",
year = "2007",
month = "3",
day = "29",
doi = "10.1021/ol070173u",
language = "English (US)",
volume = "9",
pages = "1327--1329",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

AU - Wilson, Erica M.

AU - Trauner, Dirk

PY - 2007/3/29

Y1 - 2007/3/29

N2 - Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

AB - Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

UR - http://www.scopus.com/inward/record.url?scp=34147112254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147112254&partnerID=8YFLogxK

U2 - 10.1021/ol070173u

DO - 10.1021/ol070173u

M3 - Article

C2 - 17338537

AN - SCOPUS:34147112254

VL - 9

SP - 1327

EP - 1329

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 7

ER -