Computer simulation of voltage sensitive calcium ion channels in a dendritic spine

Pilhwa Lee, Eric A. Sobie, Charles Peskin

Research output: Contribution to journalArticle

Abstract

Membrane current through voltage-sensitive calcium ion channels at the postsynaptic density of a dendritic spine is investigated. To simulate the ion channels that carry such current and the resulting temporal and spatial distribution of concentration, current, and voltage within the dendritic spine, the immersed boundary method with electrodiffusion is applied. In this simulation method a spatially continuous chemical potential barrier is used to simulate the influence of the membrane on each species of ion. The amplitudes of these barriers can be regulated to simulate channel gating. Here we introduce this methodology in a one-dimensional setting. First, we study the current-voltage relationship obtained with fixed chemical potential barriers. Next, we simulate stochastic ion-channel gating in a calcium channel with multiple subunits, and observe the diffusive wave of calcium entry within the dendritic spine that follows channel opening. This work lays the foundation for future three-dimensional studies of electrodiffusion and advection electrodiffusion in dendritic spines.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalJournal of Theoretical Biology
Volume338
DOIs
StatePublished - Dec 7 2013

Fingerprint

Dendritic Spines
Ion Channels
Spine
ion channels
Calcium Channels
Calcium
computer simulation
Computer Simulation
Chemical potential
Voltage
calcium
Computer simulation
Ions
Electric potential
Chemical Potential
Membranes
Ion Channel Gating
calcium channels
Membrane Currents
Advection

Keywords

  • Continuous-time Markov process
  • Current-voltage relationship
  • Electrodiffusion
  • The immersed boundary method

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Modeling and Simulation
  • Statistics and Probability
  • Applied Mathematics

Cite this

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine. / Lee, Pilhwa; Sobie, Eric A.; Peskin, Charles.

In: Journal of Theoretical Biology, Vol. 338, 07.12.2013, p. 87-93.

Research output: Contribution to journalArticle

Lee, Pilhwa ; Sobie, Eric A. ; Peskin, Charles. / Computer simulation of voltage sensitive calcium ion channels in a dendritic spine. In: Journal of Theoretical Biology. 2013 ; Vol. 338. pp. 87-93.
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