Compressive spatial summation in human visual cortex

Kendrick N. Kay, Jonathan Winawer, Aviv Mezer, Brian A. Wandell

Research output: Contribution to journalArticle

Abstract

Neurons within a small (a few cubic millimeters) region of visual cortex respond to stimuli within a restricted region of the visual field. Previous studies have characterized the population response of such neurons using a model that sums contrast linearly across the visual field. In this study, we tested linear spatial summation of population responses using blood oxygenation level-dependent (BOLD) functional MRI. We measured BOLD responses to a systematic set of contrast patterns and discovered systematic deviation from linearity: the data are more accurately explained by a model in which a compressive static nonlinearity is applied after linear spatial summation. We found that the nonlinearity is present in early visual areas (e.g., V1, V2) and grows more pronounced in relatively anterior extrastriate areas (e.g., LO-2, VO-2). We then analyzed the effect of compressive spatial summation in terms of changes in the position and size of a viewed object. Compressive spatial summation is consistent with tolerance to changes in position and size, an important characteristic of object representation.

Original languageEnglish (US)
Pages (from-to)481-494
Number of pages14
JournalJournal of Neurophysiology
Volume110
Issue number2
DOIs
StatePublished - Jul 15 2013

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Visual Cortex
Visual Fields
Neurons
Population
Magnetic Resonance Imaging

Keywords

  • fMRI
  • Human visual cortex
  • Population receptive field
  • Spatial nonlinearity
  • Spatial summation

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Medicine(all)

Cite this

Kay, K. N., Winawer, J., Mezer, A., & Wandell, B. A. (2013). Compressive spatial summation in human visual cortex. Journal of Neurophysiology, 110(2), 481-494. https://doi.org/10.1152/jn.00105.2013

Compressive spatial summation in human visual cortex. / Kay, Kendrick N.; Winawer, Jonathan; Mezer, Aviv; Wandell, Brian A.

In: Journal of Neurophysiology, Vol. 110, No. 2, 15.07.2013, p. 481-494.

Research output: Contribution to journalArticle

Kay, KN, Winawer, J, Mezer, A & Wandell, BA 2013, 'Compressive spatial summation in human visual cortex', Journal of Neurophysiology, vol. 110, no. 2, pp. 481-494. https://doi.org/10.1152/jn.00105.2013
Kay, Kendrick N. ; Winawer, Jonathan ; Mezer, Aviv ; Wandell, Brian A. / Compressive spatial summation in human visual cortex. In: Journal of Neurophysiology. 2013 ; Vol. 110, No. 2. pp. 481-494.
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