Comparison of maternal and cord blood polymorphonuclear leukocyte elastase levels

Edward Adeyemi, Abdishakur Abdulle

    Research output: Contribution to journalArticle

    Abstract

    The main objective of this study was to examine the influence of parturition on the polymorphonuclear leukocyte elastase release in the fetus and the mother. There were 32 babies and parturients. The mean arterial cord blood elastase level was 294.8 ± 129.15 ng/ml (median 304.25), while the mean plasma (venous) level in the adult normal controls was 35.66 ± 14.1 ng/ml. The difference was highly significant at p < 0.0001 (Student's t test, two-tailed). The mean elastase level of the mothers was 143.45 ± 109 ng/ml (median 115.25). This was significantly lower than the mean arterial cord blood elastase level (p < 0.0001) but higher than the mean elastase level in healthy adults (p < 0.0001). The mean cord blood and the mothers' white blood cell counts were 11.9 ± 3.1 (median 11.8, range 6.3-18.7 x 109/1) and 12.4 ± 2.8 (median 12.4, range 7.3-17.1 x 109/1) respectively. The difference was not statistically significant (p = O.4). The WBC counts correlated significantly with the mothers' (r = 0.4, p = 0.03) and cord blood (r = 0.7, p < 0.0001) elastase levels. These results suggest that the raised arterial cord blood elastase levels during parturition may reflect the disturbance of fetal homeostasis during parturition.

    Original languageEnglish (US)
    Pages (from-to)89-93
    Number of pages5
    JournalJournal of Perinatal Medicine
    Volume26
    Issue number2
    DOIs
    StatePublished - Jan 1 1998

    Fingerprint

    Leukocyte Elastase
    Pancreatic Elastase
    Fetal Blood
    Mothers
    Parturition
    Leukocyte Count
    Fetus
    Homeostasis
    Students

    Keywords

    • Arterial cord blood
    • Healthy neonates and mothers
    • Polymorphonuclear leukocyte elastase

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

    Cite this

    Comparison of maternal and cord blood polymorphonuclear leukocyte elastase levels. / Adeyemi, Edward; Abdulle, Abdishakur.

    In: Journal of Perinatal Medicine, Vol. 26, No. 2, 01.01.1998, p. 89-93.

    Research output: Contribution to journalArticle

    Adeyemi, Edward ; Abdulle, Abdishakur. / Comparison of maternal and cord blood polymorphonuclear leukocyte elastase levels. In: Journal of Perinatal Medicine. 1998 ; Vol. 26, No. 2. pp. 89-93.
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