Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice

Wieslawa Kosinska, Edward Pelle, Marcia d M Von Pressentin, Michael Chen, Joseph Guttenplan

Research output: Contribution to journalArticle

Abstract

Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalCancer Letters
Volume187
Issue number1-2
DOIs
StatePublished - Dec 10 2002

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Bleomycin
Kidney
Liver
Reactive Oxygen Species
Lung
Mutagenesis
ferric nitrilotriacetate

Keywords

  • Bleomycin
  • Ferric nitrilotriacetate
  • lacZ
  • Mutagenesis
  • Reactive oxygen species

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice. / Kosinska, Wieslawa; Pelle, Edward; Von Pressentin, Marcia d M; Chen, Michael; Guttenplan, Joseph.

In: Cancer Letters, Vol. 187, No. 1-2, 10.12.2002, p. 41-46.

Research output: Contribution to journalArticle

Kosinska, Wieslawa ; Pelle, Edward ; Von Pressentin, Marcia d M ; Chen, Michael ; Guttenplan, Joseph. / Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice. In: Cancer Letters. 2002 ; Vol. 187, No. 1-2. pp. 41-46.
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