Comparative genomics of trypanosomatid parasitic protozoa

Najib M. El-Sayed, Peter J. Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A. Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C. Bartholomeu, Brian J. Haas, Anh Nhi Tran, Jennifer R. Wortman, U. Cecilia M Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan BadgerFrederic Bringaud, Eithon Cadag, Jane M. Carlton, Gustavo C. Cerqueira, Todd Creasy, Arthur L. Delcher, Appolinaire Djikeng, T. Martin Embley, Christopher Hauser, Alasdair C. Ivens, Sarah K. Kummerfeld, Jose B. Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L. Salzberg, Joshua Shallom, Joana C. Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E. Melville, John E. Donelson, Björn Andersson, Kenneth D. Stuart, Neil Hall

Research output: Contribution to journalArticle

Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

Original languageEnglish (US)
JournalScience
Volume309
Issue number5733
DOIs
StatePublished - Jul 15 2005

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Genomics
Genes
Genome
Leishmania major
Retroelements
Trypanosoma brucei brucei
Trypanosoma cruzi
Proteome
Surface Antigens
Multigene Family
Life Cycle Stages
Parasites
Chromosomes
RNA
Pathology

ASJC Scopus subject areas

  • General

Cite this

El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., ... Hall, N. (2005). Comparative genomics of trypanosomatid parasitic protozoa. Science, 309(5733). https://doi.org/10.1126/science.1112181

Comparative genomics of trypanosomatid parasitic protozoa. / El-Sayed, Najib M.; Myler, Peter J.; Blandin, Gaëlle; Berriman, Matthew; Crabtree, Jonathan; Aggarwal, Gautam; Caler, Elisabet; Renauld, Hubert; Worthey, Elizabeth A.; Hertz-Fowler, Christiane; Ghedin, Elodie; Peacock, Christopher; Bartholomeu, Daniella C.; Haas, Brian J.; Tran, Anh Nhi; Wortman, Jennifer R.; Alsmark, U. Cecilia M; Angiuoli, Samuel; Anupama, Atashi; Badger, Jonathan; Bringaud, Frederic; Cadag, Eithon; Carlton, Jane M.; Cerqueira, Gustavo C.; Creasy, Todd; Delcher, Arthur L.; Djikeng, Appolinaire; Embley, T. Martin; Hauser, Christopher; Ivens, Alasdair C.; Kummerfeld, Sarah K.; Pereira-Leal, Jose B.; Nilsson, Daniel; Peterson, Jeremy; Salzberg, Steven L.; Shallom, Joshua; Silva, Joana C.; Sundaram, Jaideep; Westenberger, Scott; White, Owen; Melville, Sara E.; Donelson, John E.; Andersson, Björn; Stuart, Kenneth D.; Hall, Neil.

In: Science, Vol. 309, No. 5733, 15.07.2005.

Research output: Contribution to journalArticle

El-Sayed, NM, Myler, PJ, Blandin, G, Berriman, M, Crabtree, J, Aggarwal, G, Caler, E, Renauld, H, Worthey, EA, Hertz-Fowler, C, Ghedin, E, Peacock, C, Bartholomeu, DC, Haas, BJ, Tran, AN, Wortman, JR, Alsmark, UCM, Angiuoli, S, Anupama, A, Badger, J, Bringaud, F, Cadag, E, Carlton, JM, Cerqueira, GC, Creasy, T, Delcher, AL, Djikeng, A, Embley, TM, Hauser, C, Ivens, AC, Kummerfeld, SK, Pereira-Leal, JB, Nilsson, D, Peterson, J, Salzberg, SL, Shallom, J, Silva, JC, Sundaram, J, Westenberger, S, White, O, Melville, SE, Donelson, JE, Andersson, B, Stuart, KD & Hall, N 2005, 'Comparative genomics of trypanosomatid parasitic protozoa', Science, vol. 309, no. 5733. https://doi.org/10.1126/science.1112181
El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G et al. Comparative genomics of trypanosomatid parasitic protozoa. Science. 2005 Jul 15;309(5733). https://doi.org/10.1126/science.1112181
El-Sayed, Najib M. ; Myler, Peter J. ; Blandin, Gaëlle ; Berriman, Matthew ; Crabtree, Jonathan ; Aggarwal, Gautam ; Caler, Elisabet ; Renauld, Hubert ; Worthey, Elizabeth A. ; Hertz-Fowler, Christiane ; Ghedin, Elodie ; Peacock, Christopher ; Bartholomeu, Daniella C. ; Haas, Brian J. ; Tran, Anh Nhi ; Wortman, Jennifer R. ; Alsmark, U. Cecilia M ; Angiuoli, Samuel ; Anupama, Atashi ; Badger, Jonathan ; Bringaud, Frederic ; Cadag, Eithon ; Carlton, Jane M. ; Cerqueira, Gustavo C. ; Creasy, Todd ; Delcher, Arthur L. ; Djikeng, Appolinaire ; Embley, T. Martin ; Hauser, Christopher ; Ivens, Alasdair C. ; Kummerfeld, Sarah K. ; Pereira-Leal, Jose B. ; Nilsson, Daniel ; Peterson, Jeremy ; Salzberg, Steven L. ; Shallom, Joshua ; Silva, Joana C. ; Sundaram, Jaideep ; Westenberger, Scott ; White, Owen ; Melville, Sara E. ; Donelson, John E. ; Andersson, Björn ; Stuart, Kenneth D. ; Hall, Neil. / Comparative genomics of trypanosomatid parasitic protozoa. In: Science. 2005 ; Vol. 309, No. 5733.
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AU - Berriman, Matthew

AU - Crabtree, Jonathan

AU - Aggarwal, Gautam

AU - Caler, Elisabet

AU - Renauld, Hubert

AU - Worthey, Elizabeth A.

AU - Hertz-Fowler, Christiane

AU - Ghedin, Elodie

AU - Peacock, Christopher

AU - Bartholomeu, Daniella C.

AU - Haas, Brian J.

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AU - Angiuoli, Samuel

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AU - Badger, Jonathan

AU - Bringaud, Frederic

AU - Cadag, Eithon

AU - Carlton, Jane M.

AU - Cerqueira, Gustavo C.

AU - Creasy, Todd

AU - Delcher, Arthur L.

AU - Djikeng, Appolinaire

AU - Embley, T. Martin

AU - Hauser, Christopher

AU - Ivens, Alasdair C.

AU - Kummerfeld, Sarah K.

AU - Pereira-Leal, Jose B.

AU - Nilsson, Daniel

AU - Peterson, Jeremy

AU - Salzberg, Steven L.

AU - Shallom, Joshua

AU - Silva, Joana C.

AU - Sundaram, Jaideep

AU - Westenberger, Scott

AU - White, Owen

AU - Melville, Sara E.

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AU - Andersson, Björn

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