Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells

Ludovic Tricoire, Kenneth A. Pelkey, Michael I. Daw, Vitor H. Sousa, Goichi Miyoshi, Brian Jeffries, Bruno Cauli, Gordon Fishell, Chris J. McBain

    Research output: Contribution to journalArticle

    Abstract

    GABAergic interneurons critically regulate cortical computation through exquisite spatiotemporal control over excitatory networks. Precision of this inhibitory control requires a remarkable diversity within interneuron populations that is largely specified during embryogenesis. Although interneurons expressing the neuronal isoform of nitric oxide synthase (nNOS) constitute the largest hippocampal interneuron cohort their origin and specification remain unknown. Thus, as neurogliaform cells (NGC) and Ivy cells (IvC) represent the main nNOS+ interneurons, we investigated their developmental origins. Although considered distinct interneuron subtypes, NGCs and IvCs exhibited similar neurochemical and electrophysiological signatures, including NPY expression and late spiking. Moreover, lineage analyses, including loss-of-function experiments and inducible fate-mapping, indicated that nNOS+ IvCs and NGCs are both derived from medial ganglionic eminence (MGE) progenitors under control of the transcription factor Nkx2-1. Surprisingly, a subset of NGCs lacking nNOS arises from caudal ganglionic eminence (CGE) progenitors. Thus, while nNOS+ NGCs and IvCs arise from MGE progenitors, a CGE origin distinguishes a discrete population of nNOS- NGCs.

    Original languageEnglish (US)
    Pages (from-to)2165-2176
    Number of pages12
    JournalJournal of Neuroscience
    Volume30
    Issue number6
    DOIs
    StatePublished - Feb 10 2010

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    Nitric Oxide Synthase Type I
    Interneurons
    Nitric Oxide Synthase
    Protein Isoforms
    Median Eminence
    Population
    Embryonic Development
    Transcription Factors

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Tricoire, L., Pelkey, K. A., Daw, M. I., Sousa, V. H., Miyoshi, G., Jeffries, B., ... McBain, C. J. (2010). Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells. Journal of Neuroscience, 30(6), 2165-2176. https://doi.org/10.1523/JNEUROSCI.5123-09.2010

    Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells. / Tricoire, Ludovic; Pelkey, Kenneth A.; Daw, Michael I.; Sousa, Vitor H.; Miyoshi, Goichi; Jeffries, Brian; Cauli, Bruno; Fishell, Gordon; McBain, Chris J.

    In: Journal of Neuroscience, Vol. 30, No. 6, 10.02.2010, p. 2165-2176.

    Research output: Contribution to journalArticle

    Tricoire, L, Pelkey, KA, Daw, MI, Sousa, VH, Miyoshi, G, Jeffries, B, Cauli, B, Fishell, G & McBain, CJ 2010, 'Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells', Journal of Neuroscience, vol. 30, no. 6, pp. 2165-2176. https://doi.org/10.1523/JNEUROSCI.5123-09.2010
    Tricoire, Ludovic ; Pelkey, Kenneth A. ; Daw, Michael I. ; Sousa, Vitor H. ; Miyoshi, Goichi ; Jeffries, Brian ; Cauli, Bruno ; Fishell, Gordon ; McBain, Chris J. / Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 6. pp. 2165-2176.
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