Common neural mechanisms supporting spatial working memory, attention and motor intention

Akiko Ikkai, Clayton E. Curtis

Research output: Contribution to journalArticle

Abstract

The prefrontal cortex (PFC) and posterior parietal cortex (PPC) are critical neural substrates for working memory. Neural activity persists in these regions during the maintenance of a working memory representation. Persistent activity, therefore, may be the neural mechanism by which information is temporarily maintained. However, the nature of the representation or what is actually being represented by this persistent activity is not well understood. In this review, we summarize the recent functional magnetic resonance imaging (fMRI) studies conducted in our laboratory that test hypotheses about the nature of persistent activity during a variety of spatial cognition tasks. We find that the same areas in the PFC and PPC that show persistent activity during the maintenance of a working memory representation also show persistent activity during the maintenance of spatial attention and the maintenance of motor intention. Therefore, we conclude that persistent activity is not specific to working memory, but instead, carries information that can be used generally to support a variety of cognitions. Specifically, activity in topographically organized maps of prioritized space in PFC and PPC could be read out to guide attention allocation, spatial memory, and motor planning.

Original languageEnglish (US)
Pages (from-to)1428-1434
Number of pages7
JournalNeuropsychologia
Volume49
Issue number6
DOIs
StatePublished - May 2011

Fingerprint

Short-Term Memory
Parietal Lobe
Prefrontal Cortex
Maintenance
Cognition
Magnetic Resonance Imaging
Spatial Memory

Keywords

  • Attention
  • FMRI
  • Motor intention
  • Parietal cortex
  • Prefrontal cortex
  • Working memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Common neural mechanisms supporting spatial working memory, attention and motor intention. / Ikkai, Akiko; Curtis, Clayton E.

In: Neuropsychologia, Vol. 49, No. 6, 05.2011, p. 1428-1434.

Research output: Contribution to journalArticle

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