Combination HIV prevention: Significance, challenges, and opportunities

Ann E. Kurth, Connie Celum, Jared M. Baeten, Sten H. Vermund, Judith N. Wasserheit

Research output: Contribution to journalArticle

Abstract

No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop "prevention packages" that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.

Original languageEnglish (US)
Pages (from-to)62-72
Number of pages11
JournalCurrent HIV/AIDS Reports
Volume8
Issue number1
DOIs
StatePublished - Mar 2011

Fingerprint

HIV
Male Circumcision
Health Services Needs and Demand
Condoms
Pandemics
Risk Reduction Behavior
Sexually Transmitted Diseases
Population
Needles
Safety
Therapeutics

Keywords

  • Antiretroviral therapy
  • Combination HIV prevention
  • HIV prevention methods
  • HIV prevention packages
  • Test and treat

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Kurth, A. E., Celum, C., Baeten, J. M., Vermund, S. H., & Wasserheit, J. N. (2011). Combination HIV prevention: Significance, challenges, and opportunities. Current HIV/AIDS Reports, 8(1), 62-72. https://doi.org/10.1007/s11904-010-0063-3

Combination HIV prevention : Significance, challenges, and opportunities. / Kurth, Ann E.; Celum, Connie; Baeten, Jared M.; Vermund, Sten H.; Wasserheit, Judith N.

In: Current HIV/AIDS Reports, Vol. 8, No. 1, 03.2011, p. 62-72.

Research output: Contribution to journalArticle

Kurth, AE, Celum, C, Baeten, JM, Vermund, SH & Wasserheit, JN 2011, 'Combination HIV prevention: Significance, challenges, and opportunities', Current HIV/AIDS Reports, vol. 8, no. 1, pp. 62-72. https://doi.org/10.1007/s11904-010-0063-3
Kurth, Ann E. ; Celum, Connie ; Baeten, Jared M. ; Vermund, Sten H. ; Wasserheit, Judith N. / Combination HIV prevention : Significance, challenges, and opportunities. In: Current HIV/AIDS Reports. 2011 ; Vol. 8, No. 1. pp. 62-72.
@article{751739fc485546a59ec8ac3141414dd4,
title = "Combination HIV prevention: Significance, challenges, and opportunities",
abstract = "No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop {"}prevention packages{"} that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.",
keywords = "Antiretroviral therapy, Combination HIV prevention, HIV prevention methods, HIV prevention packages, Test and treat",
author = "Kurth, {Ann E.} and Connie Celum and Baeten, {Jared M.} and Vermund, {Sten H.} and Wasserheit, {Judith N.}",
year = "2011",
month = "3",
doi = "10.1007/s11904-010-0063-3",
language = "English (US)",
volume = "8",
pages = "62--72",
journal = "Current HIV/AIDS Reports",
issn = "1548-3568",
publisher = "Current Science, Inc.",
number = "1",

}

TY - JOUR

T1 - Combination HIV prevention

T2 - Significance, challenges, and opportunities

AU - Kurth, Ann E.

AU - Celum, Connie

AU - Baeten, Jared M.

AU - Vermund, Sten H.

AU - Wasserheit, Judith N.

PY - 2011/3

Y1 - 2011/3

N2 - No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop "prevention packages" that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.

AB - No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop "prevention packages" that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.

KW - Antiretroviral therapy

KW - Combination HIV prevention

KW - HIV prevention methods

KW - HIV prevention packages

KW - Test and treat

UR - http://www.scopus.com/inward/record.url?scp=79952695210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952695210&partnerID=8YFLogxK

U2 - 10.1007/s11904-010-0063-3

DO - 10.1007/s11904-010-0063-3

M3 - Article

VL - 8

SP - 62

EP - 72

JO - Current HIV/AIDS Reports

JF - Current HIV/AIDS Reports

SN - 1548-3568

IS - 1

ER -