Colorectal Carcinoma in Young Females

Olusola Olofinlade, Olusegun Adeonigbagbe, Nicholas Gualtieri, Hal Freiman, Olugbenga Ogedegbe, James Robilotti

Research output: Contribution to journalArticle

Abstract

Background: We sought to study the clinicopathologic characteristics of colorectal cancer in young female patients. We also wanted to determine the association of colorectal cancer with anemia in these female patients and, finally, to determine the effect of gender on prognosis in young patients with colorectal cancer. Methods: We performed a retrospective analysis of all young patients diagnosed with colorectal cancer between 1982 and 1999 in two teaching hospitals in New York City. Results: A total of 3,546 cases of colorectal cancer were diagnosed. Sixty-one (1.63%) of these patients were young patients and 32 (0.85%) were female. Young refers to all patients in the study who were younger than 40 years of age. The clinical presentation and mean age at presentation were very similar in both male and female patients. At presentation, 87.5% of female patients had anemia compared with only 69% of male patients. Males had a statistically significant higher mean hemoglobin level compared with females (12.87 versus 10.29 g) at P = 0.0001. Seventy-nine percent of female patients compared with 86% of male patients presented with left-sided tumors. Fifty-five percent of males presented with late stage disease compared with 68% of females (P = 0.27). Female sex seemed to adversely affect the prognosis, although this did not reach statistical significance (P = 0.08). Stage of disease was associated with worse prognosis and this was independent of sex. Age and hemoglobin were not independent predictors of mortality. Conclusion: Colorectal cancer does occur in females of childbearing age who might have a tendency to present with late stage disease as evidence from this study. Young female patients with anemia should be questioned about gastrointestinal symptoms, and colorectal cancer should definitely be in the differential diagnoses. This might conceivably allow for earlier diagnosis and potential for cure in this patient group.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalSouthern Medical Journal
Volume97
Issue number3
DOIs
StatePublished - Mar 2004

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Colorectal Neoplasms
Anemia
Hemoglobins
Gastrointestinal Neoplasms
Teaching Hospitals
Early Diagnosis
Differential Diagnosis

ASJC Scopus subject areas

  • Medicine(all)

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Olofinlade, O., Adeonigbagbe, O., Gualtieri, N., Freiman, H., Ogedegbe, O., & Robilotti, J. (2004). Colorectal Carcinoma in Young Females. Southern Medical Journal, 97(3), 231-235. https://doi.org/10.1097/01.SMJ.0000072360.33202.F2

Colorectal Carcinoma in Young Females. / Olofinlade, Olusola; Adeonigbagbe, Olusegun; Gualtieri, Nicholas; Freiman, Hal; Ogedegbe, Olugbenga; Robilotti, James.

In: Southern Medical Journal, Vol. 97, No. 3, 03.2004, p. 231-235.

Research output: Contribution to journalArticle

Olofinlade, O, Adeonigbagbe, O, Gualtieri, N, Freiman, H, Ogedegbe, O & Robilotti, J 2004, 'Colorectal Carcinoma in Young Females', Southern Medical Journal, vol. 97, no. 3, pp. 231-235. https://doi.org/10.1097/01.SMJ.0000072360.33202.F2
Olofinlade O, Adeonigbagbe O, Gualtieri N, Freiman H, Ogedegbe O, Robilotti J. Colorectal Carcinoma in Young Females. Southern Medical Journal. 2004 Mar;97(3):231-235. https://doi.org/10.1097/01.SMJ.0000072360.33202.F2
Olofinlade, Olusola ; Adeonigbagbe, Olusegun ; Gualtieri, Nicholas ; Freiman, Hal ; Ogedegbe, Olugbenga ; Robilotti, James. / Colorectal Carcinoma in Young Females. In: Southern Medical Journal. 2004 ; Vol. 97, No. 3. pp. 231-235.
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