Coincident induction of long-term facilitation in Aplysia: Cooperativity between cell bodies and remote synapses

Carolyn M. Sherff, Thomas J. Carew

Research output: Contribution to journalArticle

Abstract

Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Evidence is presented here that if Aplysia sensory neuron somata and their remote motor neuron synapses are simultaneously exposed to serotonin pulses insufficient to induce long-term facilitation (LTF) at either site alone, processes activated at these sites interact to induce LTF. This coincident induction of LTF requires that (i) the synaptic pulse occur within a brief temporal window of the somatic pulse, and (ii) local protein synthesis occur immediately at the synapse, followed by delayed protein synthesis at the soma.

Original languageEnglish (US)
Pages (from-to)1911-1914
Number of pages4
JournalScience
Volume285
Issue number5435
DOIs
StatePublished - Sep 17 1999

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Aplysia
Synapses
Carisoprodol
Motor Neurons
Sensory Receptor Cells
Serotonin
Proteins
Cell Body

ASJC Scopus subject areas

  • General

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Coincident induction of long-term facilitation in Aplysia : Cooperativity between cell bodies and remote synapses. / Sherff, Carolyn M.; Carew, Thomas J.

In: Science, Vol. 285, No. 5435, 17.09.1999, p. 1911-1914.

Research output: Contribution to journalArticle

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