Coincident induction of long-term facilitation at sensory-motor synapses in Aplysia

Presynaptic and postsynaptic factors

Carolyn M. Sherff, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Here we show that if Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, which at either site alone are insufficient to induce long-term facilitation (LTF), processes activated at these sites interact to induce LTF. Coincident induction of LTF requires: (1) that the synaptic pulse occurs within a brief temporal window of the somatic pulse and (2) that local protein synthesis occurs immediately at the synapse, followed by delayed protein synthesis at the soma. LTF at the SN-MN synapses can also be induced with cell-wide application of repeated pulses of 5HT. However, these two forms of LTF differ mechanistically: (1) coincident LTF requires protein synthesis in the postsynaptic motor neuron, whereas repeated 5HT LTF does not, and (2) repeated 5HT LTF is accompanied by intermediate-term (3 h) facilitation, whereas coincident LTF is not. Thus LTF expressed in the same temporal domain can result from different underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)498-507
Number of pages10
JournalNeurobiology of Learning and Memory
Volume78
Issue number3
DOIs
StatePublished - Nov 2002

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Aplysia
Synapses
Motor Neurons
Carisoprodol
Sensory Receptor Cells
Proteins
Serotonin

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Coincident induction of long-term facilitation at sensory-motor synapses in Aplysia : Presynaptic and postsynaptic factors. / Sherff, Carolyn M.; Carew, Thomas.

In: Neurobiology of Learning and Memory, Vol. 78, No. 3, 11.2002, p. 498-507.

Research output: Contribution to journalArticle

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