Cognition in multiple sclerosis: A review of neuropsychological and fMRI research

Helen M. Genova, James F. Sumowski, Nancy Chiaravalloti, Gerald Voelbel, John Deluca

Research output: Contribution to journalReview article

Abstract

Multiple Sclerosis (MS) is a disease of the central nervous system affecting millions of people worldwide. In addition to the disabling physical symptoms of MS, roughly 65% of individuals with MS also experience significant cognitive dysfunction, especially in the domains of learning/memory, processing speed (PS) and working memory (WM). The purpose of this review is to examine major topics in research on cognitive dysfunction, as well as review recent functional magnetic resonance imaging (fMRI) studies focusing on cognitive dysfunction in MS. Additionally, directions for future research are discussed.

Original languageEnglish (US)
Pages (from-to)1730-1744
Number of pages15
JournalFrontiers in Bioscience
Volume14
Issue number5
DOIs
StatePublished - Jan 1 2009

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Cognition
Multiple Sclerosis
Magnetic Resonance Imaging
Data storage equipment
Neurology
Research
Central Nervous System Diseases
Processing
Short-Term Memory
Learning
Cognitive Dysfunction
Direction compound

Keywords

  • Attention
  • Cognitive dysfunction
  • Cognitive fatigue
  • Episodic memory
  • Executive function
  • fMRI
  • Functional magnetic resonance imaging
  • Learning and memory
  • Multiple sclerosis
  • Processing speed
  • Review
  • Visual perception
  • Working memory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Cognition in multiple sclerosis : A review of neuropsychological and fMRI research. / Genova, Helen M.; Sumowski, James F.; Chiaravalloti, Nancy; Voelbel, Gerald; Deluca, John.

In: Frontiers in Bioscience, Vol. 14, No. 5, 01.01.2009, p. 1730-1744.

Research output: Contribution to journalReview article

Genova, HM, Sumowski, JF, Chiaravalloti, N, Voelbel, G & Deluca, J 2009, 'Cognition in multiple sclerosis: A review of neuropsychological and fMRI research', Frontiers in Bioscience, vol. 14, no. 5, pp. 1730-1744. https://doi.org/10.2741/3336
Genova, Helen M. ; Sumowski, James F. ; Chiaravalloti, Nancy ; Voelbel, Gerald ; Deluca, John. / Cognition in multiple sclerosis : A review of neuropsychological and fMRI research. In: Frontiers in Bioscience. 2009 ; Vol. 14, No. 5. pp. 1730-1744.
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