Co-transcriptional nuclear actin dynamics

Piergiorgio Percipalle

    Research output: Contribution to journalReview article

    Abstract

    Actin is a key player for nuclear structure and function regulating both chromosome organization and gene activity. In the cell nucleus actin interacts with many different proteins. Among these proteins several studies have identified classical nuclear factors involved in chromatin structure and function, transcription and RNA processing as well as proteins that are normally involved in controlling the actin cytoskeleton. These discoveries have raised the possibility that nuclear actin performs its multi task activities through tight interactions with different sets of proteins. This high degree of promiscuity in the spectrum of protein-to-protein interactions correlates well with the conformational plasticity of actin and the ability to undergo regulated changes in its polymerization states. Several of the factors involved in controlling head-to-tail actin polymerization have been shown to be in the nucleus where they seem to regulate gene activity. By focusing on the multiple tasks performed by actin and actin-binding proteins, possible models of how actin dynamics controls the different phases of the RNA polymerase II transcription cycle are being identified.

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalNucleus (United States)
    Volume4
    Issue number1
    DOIs
    StatePublished - Feb 14 2013

    Fingerprint

    Actins
    Proteins
    Polymerization
    Microfilament Proteins
    RNA Polymerase II
    Cell Nucleus
    Actin Cytoskeleton
    Genes
    Chromatin
    Chromosomes
    RNA

    Keywords

    • Actin polymerization
    • Nuclear actin
    • Nuclear structure and function
    • RNA polymerase
    • Transcription

    ASJC Scopus subject areas

    • Cell Biology

    Cite this

    Co-transcriptional nuclear actin dynamics. / Percipalle, Piergiorgio.

    In: Nucleus (United States), Vol. 4, No. 1, 14.02.2013, p. 1-10.

    Research output: Contribution to journalReview article

    Percipalle, Piergiorgio. / Co-transcriptional nuclear actin dynamics. In: Nucleus (United States). 2013 ; Vol. 4, No. 1. pp. 1-10.
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