Clogging of microfluidic systems

Emilie Dressaire, Alban Sauret

Research output: Contribution to journalReview article

Abstract

The transport of suspensions of microparticles in confined environments is associated with complex phenomena at the interface of fluid mechanics and soft matter. Indeed, the deposition and assembly of particles under flow involve hydrodynamic, steric and colloidal forces, and can lead to the clogging of microchannels. The formation of clogs dramatically alters the performance of both natural and engineered systems, effectively limiting the use of microfluidic technology. While the fouling of porous filters has been studied at the macroscopic level, it is only recently that the formation of clogs has been considered at the pore-scale, using microfluidic devices. In this review, we present the clogging mechanisms recently reported for suspension flows of colloidal particles and for biofluids in microfluidic channels, including sieving, bridging and aggregation of particles. We discuss the technological implications of the clogging of microchannels and the schemes that leverage the formation of clogs. We finally consider some of the outstanding challenges involving clogging in human health, which could be tackled with microfluidic methods.

Original languageEnglish (US)
Pages (from-to)37-48
Number of pages12
JournalSoft Matter
Volume13
Issue number1
DOIs
StatePublished - 2017

Fingerprint

plugging
Microfluidics
microchannels
Microchannels
Suspensions
fouling
fluid mechanics
microfluidic devices
Fluid mechanics
microparticles
Fouling
health
Agglomeration
Hydrodynamics
assembly
hydrodynamics
Health
porosity
filters

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Dressaire, E., & Sauret, A. (2017). Clogging of microfluidic systems. Soft Matter, 13(1), 37-48. https://doi.org/10.1039/C6SM01879C

Clogging of microfluidic systems. / Dressaire, Emilie; Sauret, Alban.

In: Soft Matter, Vol. 13, No. 1, 2017, p. 37-48.

Research output: Contribution to journalReview article

Dressaire, E & Sauret, A 2017, 'Clogging of microfluidic systems', Soft Matter, vol. 13, no. 1, pp. 37-48. https://doi.org/10.1039/C6SM01879C
Dressaire, Emilie ; Sauret, Alban. / Clogging of microfluidic systems. In: Soft Matter. 2017 ; Vol. 13, No. 1. pp. 37-48.
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