Clinical burden of herpes simplex virus disease in people with human immunodeficiency virus

Tamarind M. Keating, Ann E. Kurth, Anna Wald, Erin M. Kahle, Elizabeth A. Barash, Susan E. Buskin

Research output: Contribution to journalArticle

Abstract

Background: Serologic studies indicate that herpes simplex virus (HSV)-1 and HSV-2 infections are highly prevalent among people infected with HIV. As an ulcerative genital disease, HSV may be important to HIV transmission and HIV-comorbidity. Routine clinical care of HSV in this population has not been described. Methods: Data were abstracted from medical records of HIV-infected individuals by the Adult/Adolescent Spectrum of HIV Disease Project. Clinician-documented HSV diagnosis and HSV treatment, defined as any prescription for acyclovir, valacyclovir, or famciclovir, were the outcomes of interest. We present descriptive statistics and trends in HSV diagnosis and treatment. Results: Between 1989 and 2004, 61,299 people were followed in this study. HSV was diagnosed in 20% of the population, and 32% of the population received HSV antiviral prescriptions. Prescriptions for episodic treatment were given to 28% of patients, and 11% received prescriptions for suppressive therapy. The average annual rate of HSV diagnosis declined by 31% during the course of the study. Conclusions: Clinically recognized HSV infections were frequent despite declining rates of diagnosis. Providers should have a high index of suspicion for HSV and consider routine screening and suppressive therapy for patients at risk of clinical disease.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalSexually Transmitted Diseases
Volume39
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Virus Diseases
Simplexvirus
HIV
Prescriptions
valacyclovir
Population
Therapeutics
Herpes Genitalis
Human Herpesvirus 2
Acyclovir
Human Herpesvirus 1
Medical Records
Antiviral Agents
Comorbidity

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Keating, T. M., Kurth, A. E., Wald, A., Kahle, E. M., Barash, E. A., & Buskin, S. E. (2012). Clinical burden of herpes simplex virus disease in people with human immunodeficiency virus. Sexually Transmitted Diseases, 39(5), 372-376. https://doi.org/10.1097/OLQ.0b013e318244ac4c

Clinical burden of herpes simplex virus disease in people with human immunodeficiency virus. / Keating, Tamarind M.; Kurth, Ann E.; Wald, Anna; Kahle, Erin M.; Barash, Elizabeth A.; Buskin, Susan E.

In: Sexually Transmitted Diseases, Vol. 39, No. 5, 05.2012, p. 372-376.

Research output: Contribution to journalArticle

Keating, Tamarind M. ; Kurth, Ann E. ; Wald, Anna ; Kahle, Erin M. ; Barash, Elizabeth A. ; Buskin, Susan E. / Clinical burden of herpes simplex virus disease in people with human immunodeficiency virus. In: Sexually Transmitted Diseases. 2012 ; Vol. 39, No. 5. pp. 372-376.
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