Circulating IGF-1 and Its Role in Cancer

Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion

Shoshana Yakar, Patricia Pennisi, Hong Zhao, Yang Zhang, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.

Original languageEnglish (US)
Title of host publicationBiology of IGF-1
Subtitle of host publicationIts Interaction with Insulin in Health and Malignant States
Publisherwiley
Pages3-17
Number of pages15
Volume262
ISBN (Electronic)9780470869970
ISBN (Print)9780470869987
DOIs
StatePublished - Oct 7 2008

Fingerprint

Gene Deletion
Insulin-Like Growth Factor I
Neoplasms
Colonic Neoplasms
Epidemiologic Studies
Reference Values
Breast Neoplasms
Neoplasm Metastasis
Growth
Serum

Keywords

  • Acid labile subunit (ALS) null gene
  • Blocking peptides and blocking antibodies
  • Circulating IGF-1 levels
  • IGF binding proteins (IGFBPs)
  • IGF-1R tyrosine kinase inhibitors
  • IGFs and cancer
  • Insulin-like growth factors (IGFs)
  • LID mice
  • Serum IGF-1 and cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yakar, S., Pennisi, P., Zhao, H., Zhang, Y., & LeRoith, D. (2008). Circulating IGF-1 and Its Role in Cancer: Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion. In Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States (Vol. 262, pp. 3-17). wiley. https://doi.org/10.1002/0470869976.ch2

Circulating IGF-1 and Its Role in Cancer : Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion. / Yakar, Shoshana; Pennisi, Patricia; Zhao, Hong; Zhang, Yang; LeRoith, Derek.

Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States. Vol. 262 wiley, 2008. p. 3-17.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yakar, S, Pennisi, P, Zhao, H, Zhang, Y & LeRoith, D 2008, Circulating IGF-1 and Its Role in Cancer: Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion. in Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States. vol. 262, wiley, pp. 3-17. https://doi.org/10.1002/0470869976.ch2
Yakar S, Pennisi P, Zhao H, Zhang Y, LeRoith D. Circulating IGF-1 and Its Role in Cancer: Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion. In Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States. Vol. 262. wiley. 2008. p. 3-17 https://doi.org/10.1002/0470869976.ch2
Yakar, Shoshana ; Pennisi, Patricia ; Zhao, Hong ; Zhang, Yang ; LeRoith, Derek. / Circulating IGF-1 and Its Role in Cancer : Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion. Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States. Vol. 262 wiley, 2008. pp. 3-17
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