Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse

Shoshana Yakar, Patricia Pennisi, Hong Zhao, Yang Zhang, Derek LeRoith, Meyts De Meyts

Research output: Contribution to journalArticle

Abstract

Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.

Original languageEnglish (US)
Pages (from-to)3-18
Number of pages16
JournalNovartis Foundation Symposium
Volume262
StatePublished - Dec 1 2004

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yakar, S., Pennisi, P., Zhao, H., Zhang, Y., LeRoith, D., & De Meyts, M. (2004). Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse. Novartis Foundation Symposium, 262, 3-18.