Circuits and programmable self-assembling DNA structures

Alessandra Carbone, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

Self-assembly is beginning to be seen as a practical vehicle for computation. We investigate how basic ideas on tiling can be applied to the assembly and evaluation of circuits. We suggest that these procedures can be realized on the molecular scale through the medium of self-assembled DNA tiles. One layer of self-assembled DNA tiles will be used as the program or circuit that leads to the computation of a particular Boolean expression. This layer templates the assembly of tiles, and their associations then lead to the actual evaluation involving the input data. We describe DNA motifs that can be used for this purpose; we show how the template layer can be programmed, in much the way that a general-purpose computer can run programs for a variety of applications. The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers.

Original languageEnglish (US)
Pages (from-to)12577-12582
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number20
DOIs
StatePublished - Oct 1 2002

Fingerprint

Nucleotide Motifs
DNA

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Circuits and programmable self-assembling DNA structures. / Carbone, Alessandra; Seeman, Nadrian.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20, 01.10.2002, p. 12577-12582.

Research output: Contribution to journalArticle

@article{c0f109177f68453bbf59a3b881a70036,
title = "Circuits and programmable self-assembling DNA structures",
abstract = "Self-assembly is beginning to be seen as a practical vehicle for computation. We investigate how basic ideas on tiling can be applied to the assembly and evaluation of circuits. We suggest that these procedures can be realized on the molecular scale through the medium of self-assembled DNA tiles. One layer of self-assembled DNA tiles will be used as the program or circuit that leads to the computation of a particular Boolean expression. This layer templates the assembly of tiles, and their associations then lead to the actual evaluation involving the input data. We describe DNA motifs that can be used for this purpose; we show how the template layer can be programmed, in much the way that a general-purpose computer can run programs for a variety of applications. The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers.",
author = "Alessandra Carbone and Nadrian Seeman",
year = "2002",
month = "10",
day = "1",
doi = "10.1073/pnas.202418299",
language = "English (US)",
volume = "99",
pages = "12577--12582",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "20",

}

TY - JOUR

T1 - Circuits and programmable self-assembling DNA structures

AU - Carbone, Alessandra

AU - Seeman, Nadrian

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Self-assembly is beginning to be seen as a practical vehicle for computation. We investigate how basic ideas on tiling can be applied to the assembly and evaluation of circuits. We suggest that these procedures can be realized on the molecular scale through the medium of self-assembled DNA tiles. One layer of self-assembled DNA tiles will be used as the program or circuit that leads to the computation of a particular Boolean expression. This layer templates the assembly of tiles, and their associations then lead to the actual evaluation involving the input data. We describe DNA motifs that can be used for this purpose; we show how the template layer can be programmed, in much the way that a general-purpose computer can run programs for a variety of applications. The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers.

AB - Self-assembly is beginning to be seen as a practical vehicle for computation. We investigate how basic ideas on tiling can be applied to the assembly and evaluation of circuits. We suggest that these procedures can be realized on the molecular scale through the medium of self-assembled DNA tiles. One layer of self-assembled DNA tiles will be used as the program or circuit that leads to the computation of a particular Boolean expression. This layer templates the assembly of tiles, and their associations then lead to the actual evaluation involving the input data. We describe DNA motifs that can be used for this purpose; we show how the template layer can be programmed, in much the way that a general-purpose computer can run programs for a variety of applications. The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers.

UR - http://www.scopus.com/inward/record.url?scp=0036792081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036792081&partnerID=8YFLogxK

U2 - 10.1073/pnas.202418299

DO - 10.1073/pnas.202418299

M3 - Article

VL - 99

SP - 12577

EP - 12582

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 20

ER -